Serum hyaluronic acid as a reliable parameter of allograft viability in porcine liver transplantation

Yuji Soejima, Katsuhiko Yanaga, Shigeki Wakiyama, Takashi Nishizaki, Tomoharu Yoshizumi, Keizo Sugimachi

Research output: Contribution to journalArticle

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Abstract

Background/Aims: Hyaluronic acid is an endogenous glycosaminoglycan which is selectively degraded by hepatic sinusoidal endothelial cells. We evaluated the significance of serum hyaluronic acid clearance as an early indicator of allograft viability in porcine Liver transplantation. Materials and Methods: According to the survival period, animals were divided into two groups: Group I (n = 8) for survival equal or over four days and Group II (n = 5) for survival less than four days. Serial serum hyaluronic acid concentrations were measured before and after reperfusion in the recipient. Results: In both groups, serum hyaluronic acid levels during the anhepatic period increased rapidly 9-fold from the preoperative value due to the absence of clearance by hepatic endothelial cells. In Group I, serum hyaluronic acid peaked at 15 min postreperfusion and decreased thereafter. In contrast, Group II failed to show clearance of hyaluronic acid after reperfusion. The serum hyaluronic acid value 120 min after reperfusion was 1,029 ± 357 μg/L in Group I, and 1,856 ± 263 μg/L in Group II (p < 0.01). Conventional parameters of liver function such as aspartate transaminase, lactic dehydrogenase, ammonia, lactate, and total bile acids were comparable between the two groups. Conclusions: The clearance of the serum hyaluronic acid reflects hepatic sinusoidal endothelial cell function and is a reliable and early marker of hepatic allograft viability.

Original languageEnglish
Pages (from-to)590-595
Number of pages6
JournalHepato-gastroenterology
Volume43
Issue number9
Publication statusPublished - Jul 4 1996

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Hyaluronic Acid
Liver Transplantation
Allografts
Swine
Serum
Reperfusion
Endothelial Cells
Liver
Aspartate Aminotransferases
Glycosaminoglycans
Bile Acids and Salts
L-Lactate Dehydrogenase
Ammonia
Hepatocytes
Milk

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Soejima, Y., Yanaga, K., Wakiyama, S., Nishizaki, T., Yoshizumi, T., & Sugimachi, K. (1996). Serum hyaluronic acid as a reliable parameter of allograft viability in porcine liver transplantation. Hepato-gastroenterology, 43(9), 590-595.

Serum hyaluronic acid as a reliable parameter of allograft viability in porcine liver transplantation. / Soejima, Yuji; Yanaga, Katsuhiko; Wakiyama, Shigeki; Nishizaki, Takashi; Yoshizumi, Tomoharu; Sugimachi, Keizo.

In: Hepato-gastroenterology, Vol. 43, No. 9, 04.07.1996, p. 590-595.

Research output: Contribution to journalArticle

Soejima, Y, Yanaga, K, Wakiyama, S, Nishizaki, T, Yoshizumi, T & Sugimachi, K 1996, 'Serum hyaluronic acid as a reliable parameter of allograft viability in porcine liver transplantation', Hepato-gastroenterology, vol. 43, no. 9, pp. 590-595.
Soejima, Yuji ; Yanaga, Katsuhiko ; Wakiyama, Shigeki ; Nishizaki, Takashi ; Yoshizumi, Tomoharu ; Sugimachi, Keizo. / Serum hyaluronic acid as a reliable parameter of allograft viability in porcine liver transplantation. In: Hepato-gastroenterology. 1996 ; Vol. 43, No. 9. pp. 590-595.
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