Serum hyaluronic acid for the assessment of graft viability in porcine liver transplantation

Hidetoshi Itasaka, Keiji Kishikawa, Taketoshi Suehiro, Katsuhiko Yanaga, Mitsuo Shimada, Hidefumi Higashi, Saburo Kakizoe, Tetsuo Ikeda, Shigeki Wakiyama, Keizo Sugimachi

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

For the assessment of graft viability, serum hyaluronic acid (HA) levels during porcine orthotopic liver transplantation were measured in two groups: group 1 (viable:n = 5) in which allografts were transplanted following a minimal cold (4°C) preservation, and group 2 (nonviable:n = 4) in which allografts were transplanted after cold static storage (4°C) for 24 h in University of Wisconsin solution. The changes in the HA levels reached a significant difference between the two groups at 30 min after reperfusion (P < 0.02). In group 1, all animals survived for over 4 days, while all animals in group 2 died within 24 h. The serum HA also demonstrated a significant correlation with prothrombin time, ß-glucuronidase, and aspartate aminotransferase at 120 min after reperfusion. These results suggest that the measurement of serum HA is a potentially effective index for evaluating hepatic allograft viability.

Original languageEnglish
Pages (from-to)719-724
Number of pages6
JournalSurgery today
Volume24
Issue number8
DOIs
Publication statusPublished - Aug 1 1994

All Science Journal Classification (ASJC) codes

  • Surgery

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