Serum neutrophil gelatinase-associated lipocalin as a predictor of the development of bronchopulmonary dysplasia in preterm infants

Hirosuke Inoue, Shoichi Ohga, Takeshi Kusuda, Junko Kitajima, Tadamune Kinjo, Masayuki Ochiai, Yasushi Takahata, Satoshi Honjo, Toshiro Hara

Research output: Contribution to journalArticle

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Abstract

Background: Bronchopulmonary dysplasia (BPD) is a chronic lung disease mostly occurring in preterm infants. The pathogenesis of BPD involves early inflammation and remodeling of the premature lung. Aim: To search for the novel predictive marker of BPD development, we studied serum levels of neutrophil gelatinase-associated lipocalin (NGAL), an innate immune mediator, in preterm infants. Methods: Serum NGAL concentrations at birth were measured by enzyme-linked immunosorbent assay. The reference levels were determined in 52 infants having no anomalies or inherited diseases. The levels and clinical variables were assessed in association with BPD. Results: Geometric means (95%CI) of serum NGAL levels at birth of infants having no underlying diseases were 32.4 (22.1-47.5), 58.6 (47.9-71.8), and 126.2 (99.0-168.7) ng/mL for <. 31, 31-36 and >. 36 gestational weeks (GW), respectively (p. <. 0.001). These levels positively correlated with neutrophil (p. <. 0.0001) or monocyte counts (p. <. 0.0001). The median NGAL levels (307.8. ng/mL) and neutrophil counts (4141/μL) at birth of 16 preterm infants (<. 31. GW) who developed BPD were higher than those (42.9. ng/mL and 1357/μL) of 20 infants (<. 31. GW) who did not (p. <. 0.0001 and p=0.012), respectively. In multivariable analysis for 36 infants born less than 31. GW, higher NGAL levels (≥. 82. ng/mL) but not neutrophil counts at birth had a significant association with developing BPD (gestational-age adjusted odds ratio [OR]=37.45 [3.08-455.49], p. <. 0.01). Conclusions: High serum levels of NGAL at birth could be an early sensitive marker for BPD in preterm infants, because their levels were physiologically low.

Original languageEnglish
Pages (from-to)425-429
Number of pages5
JournalEarly Human Development
Volume89
Issue number6
DOIs
Publication statusPublished - Jun 1 2013

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Bronchopulmonary Dysplasia
Premature Infants
Parturition
Serum
Neutrophils
Lipocalin-2
Lung Diseases
Gestational Age
Monocytes
Chronic Disease
Enzyme-Linked Immunosorbent Assay
Odds Ratio
Inflammation
Lung

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

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Serum neutrophil gelatinase-associated lipocalin as a predictor of the development of bronchopulmonary dysplasia in preterm infants. / Inoue, Hirosuke; Ohga, Shoichi; Kusuda, Takeshi; Kitajima, Junko; Kinjo, Tadamune; Ochiai, Masayuki; Takahata, Yasushi; Honjo, Satoshi; Hara, Toshiro.

In: Early Human Development, Vol. 89, No. 6, 01.06.2013, p. 425-429.

Research output: Contribution to journalArticle

Inoue, Hirosuke ; Ohga, Shoichi ; Kusuda, Takeshi ; Kitajima, Junko ; Kinjo, Tadamune ; Ochiai, Masayuki ; Takahata, Yasushi ; Honjo, Satoshi ; Hara, Toshiro. / Serum neutrophil gelatinase-associated lipocalin as a predictor of the development of bronchopulmonary dysplasia in preterm infants. In: Early Human Development. 2013 ; Vol. 89, No. 6. pp. 425-429.
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T1 - Serum neutrophil gelatinase-associated lipocalin as a predictor of the development of bronchopulmonary dysplasia in preterm infants

AU - Inoue, Hirosuke

AU - Ohga, Shoichi

AU - Kusuda, Takeshi

AU - Kitajima, Junko

AU - Kinjo, Tadamune

AU - Ochiai, Masayuki

AU - Takahata, Yasushi

AU - Honjo, Satoshi

AU - Hara, Toshiro

PY - 2013/6/1

Y1 - 2013/6/1

N2 - Background: Bronchopulmonary dysplasia (BPD) is a chronic lung disease mostly occurring in preterm infants. The pathogenesis of BPD involves early inflammation and remodeling of the premature lung. Aim: To search for the novel predictive marker of BPD development, we studied serum levels of neutrophil gelatinase-associated lipocalin (NGAL), an innate immune mediator, in preterm infants. Methods: Serum NGAL concentrations at birth were measured by enzyme-linked immunosorbent assay. The reference levels were determined in 52 infants having no anomalies or inherited diseases. The levels and clinical variables were assessed in association with BPD. Results: Geometric means (95%CI) of serum NGAL levels at birth of infants having no underlying diseases were 32.4 (22.1-47.5), 58.6 (47.9-71.8), and 126.2 (99.0-168.7) ng/mL for <. 31, 31-36 and >. 36 gestational weeks (GW), respectively (p. <. 0.001). These levels positively correlated with neutrophil (p. <. 0.0001) or monocyte counts (p. <. 0.0001). The median NGAL levels (307.8. ng/mL) and neutrophil counts (4141/μL) at birth of 16 preterm infants (<. 31. GW) who developed BPD were higher than those (42.9. ng/mL and 1357/μL) of 20 infants (<. 31. GW) who did not (p. <. 0.0001 and p=0.012), respectively. In multivariable analysis for 36 infants born less than 31. GW, higher NGAL levels (≥. 82. ng/mL) but not neutrophil counts at birth had a significant association with developing BPD (gestational-age adjusted odds ratio [OR]=37.45 [3.08-455.49], p. <. 0.01). Conclusions: High serum levels of NGAL at birth could be an early sensitive marker for BPD in preterm infants, because their levels were physiologically low.

AB - Background: Bronchopulmonary dysplasia (BPD) is a chronic lung disease mostly occurring in preterm infants. The pathogenesis of BPD involves early inflammation and remodeling of the premature lung. Aim: To search for the novel predictive marker of BPD development, we studied serum levels of neutrophil gelatinase-associated lipocalin (NGAL), an innate immune mediator, in preterm infants. Methods: Serum NGAL concentrations at birth were measured by enzyme-linked immunosorbent assay. The reference levels were determined in 52 infants having no anomalies or inherited diseases. The levels and clinical variables were assessed in association with BPD. Results: Geometric means (95%CI) of serum NGAL levels at birth of infants having no underlying diseases were 32.4 (22.1-47.5), 58.6 (47.9-71.8), and 126.2 (99.0-168.7) ng/mL for <. 31, 31-36 and >. 36 gestational weeks (GW), respectively (p. <. 0.001). These levels positively correlated with neutrophil (p. <. 0.0001) or monocyte counts (p. <. 0.0001). The median NGAL levels (307.8. ng/mL) and neutrophil counts (4141/μL) at birth of 16 preterm infants (<. 31. GW) who developed BPD were higher than those (42.9. ng/mL and 1357/μL) of 20 infants (<. 31. GW) who did not (p. <. 0.0001 and p=0.012), respectively. In multivariable analysis for 36 infants born less than 31. GW, higher NGAL levels (≥. 82. ng/mL) but not neutrophil counts at birth had a significant association with developing BPD (gestational-age adjusted odds ratio [OR]=37.45 [3.08-455.49], p. <. 0.01). Conclusions: High serum levels of NGAL at birth could be an early sensitive marker for BPD in preterm infants, because their levels were physiologically low.

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