Serum pepsinogen and Helicobacter pylori infection-a Japanese population study

K. Toyoda, N. Furusyo, T. Ihara, H. Ikezaki, J. Hayashi, N. Furusyo, J. Hayashi, Y. Urita

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The decreased ratio of serum pepsinogen (PG) and II has good correlation with the presence of atrophic gastritis. A total of 1,540 residents aged 30-89 years were enrolled into this study to investigate which serum PG level of residents with Helicobacter pylori infection would represent an adjunct to the diagnosis and progression of atrophic gastritis. All participants received esophagogastroduodenoscopy. Serum antibody to H. pylori (anti-H. pylori) was measured by an enzyme-linked immunosorbent assay (ELISA). Serological atrophic gastritis was defined as serum PG I isozyme level ?70 ng/ml and a PG I/II ratio of ?3.0. Of the 1,540 participants, 923 (59.9%) were positive for anti-H. pylori. Serological atrophic gastritis was found significantly more often in anti-H. pylori-positive participants (40.8%) than in anti-H. pylori-negative participants (7.9%) (p? 0.0001). The endoscopic findings of anti-H. pylori-positive participants with serological atrophic gastritis were significantly more frequent by 4.06 times for atrophic gastritis (p? 0.0001) than anti-H. pylori-negative participants without serological atrophic gastritis. Eight anti-H. pylori-positive participants were diagnosed with gastric cancer, but no cancer was found in anti-H. pylori-negative participants without serological atrophic gastritis. Serum PG testing is clinically useful for the prediction of gastric lesions in H. pylori-infected persons.

Original languageEnglish
Pages (from-to)2117-2124
Number of pages8
JournalEuropean Journal of Clinical Microbiology and Infectious Diseases
Volume31
Issue number9
DOIs
Publication statusPublished - Sep 1 2012

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Serum pepsinogen and Helicobacter pylori infection-a Japanese population study'. Together they form a unique fingerprint.

  • Cite this