TY - JOUR
T1 - Setting reaction of α-TCP spheres and an acidic calcium phosphate solution for the fabrication of fully interconnected macroporous calcium phosphate
AU - Kien, Pham Trung
AU - Ishikawa, Kunio
AU - Tsuru, Kanji
N1 - Funding Information:
This study was supported, in part, by the Strategic Promotion of Innovative Research and Development Program ( AJ120495 ), Japan Agency for Medical Research and Development (AJ120495), and Grant-in-Aid for Scientific Research ( 24659861 ) from the Japanese Society for Promotion of Science and Research .
Publisher Copyright:
© 2015 Elsevier Ltd and Techna Group S.r.l.
PY - 2015/12
Y1 - 2015/12
N2 - Interconnected macroporous calcium phosphate has attracted attention as an artificial bone substitute as well as a scaffold for tissue engineering. In this investigation, a setting reaction between α-tricalcium phosphate (α-TCP) spheres and an acidic calcium phosphate solution (0.2 mol/L monocalcium phosphate monohydrate – 0.1 mol/L phosphoric acid) was studied to assess the feasibility of fabricating fully interconnected macroporous calcium phosphate. When 1.3 mm-diameter α-TCP spheres were exposed to an acidic calcium phosphate solution, brushite (dicalcium phosphate dihydrate) was formed on the surface of the α-TCP spheres. The precipitated brushite crystals interlocked with one another and bridged the α-TCP spheres, resulting in a 10 min setting reaction at 37 °C that produced fully interconnected macroporous calcium phosphate. The resultant calcium phosphate macroporous structure had a porosity of 49.7±2.5% and an average pore size of 312±160 μm.
AB - Interconnected macroporous calcium phosphate has attracted attention as an artificial bone substitute as well as a scaffold for tissue engineering. In this investigation, a setting reaction between α-tricalcium phosphate (α-TCP) spheres and an acidic calcium phosphate solution (0.2 mol/L monocalcium phosphate monohydrate – 0.1 mol/L phosphoric acid) was studied to assess the feasibility of fabricating fully interconnected macroporous calcium phosphate. When 1.3 mm-diameter α-TCP spheres were exposed to an acidic calcium phosphate solution, brushite (dicalcium phosphate dihydrate) was formed on the surface of the α-TCP spheres. The precipitated brushite crystals interlocked with one another and bridged the α-TCP spheres, resulting in a 10 min setting reaction at 37 °C that produced fully interconnected macroporous calcium phosphate. The resultant calcium phosphate macroporous structure had a porosity of 49.7±2.5% and an average pore size of 312±160 μm.
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U2 - 10.1016/j.ceramint.2015.07.146
DO - 10.1016/j.ceramint.2015.07.146
M3 - Article
AN - SCOPUS:84939832485
SN - 0272-8842
VL - 41
SP - 13525
EP - 13531
JO - Ceramics International
JF - Ceramics International
IS - 10
ER -