Setting reaction of α-TCP spheres and an acidic calcium phosphate solution for the fabrication of fully interconnected macroporous calcium phosphate

Pham Trung Kien, Kunio Ishikawa, Kanji Tsuru

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Interconnected macroporous calcium phosphate has attracted attention as an artificial bone substitute as well as a scaffold for tissue engineering. In this investigation, a setting reaction between α-tricalcium phosphate (α-TCP) spheres and an acidic calcium phosphate solution (0.2 mol/L monocalcium phosphate monohydrate – 0.1 mol/L phosphoric acid) was studied to assess the feasibility of fabricating fully interconnected macroporous calcium phosphate. When 1.3 mm-diameter α-TCP spheres were exposed to an acidic calcium phosphate solution, brushite (dicalcium phosphate dihydrate) was formed on the surface of the α-TCP spheres. The precipitated brushite crystals interlocked with one another and bridged the α-TCP spheres, resulting in a 10 min setting reaction at 37 °C that produced fully interconnected macroporous calcium phosphate. The resultant calcium phosphate macroporous structure had a porosity of 49.7±2.5% and an average pore size of 312±160 μm.

Original languageEnglish
Pages (from-to)13525-13531
Number of pages7
JournalCeramics International
Issue number10
Publication statusPublished - Dec 1 2015


All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Process Chemistry and Technology
  • Surfaces, Coatings and Films
  • Materials Chemistry

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