Setting reaction of α-TCP spheres and an acidic calcium phosphate solution for the fabrication of fully interconnected macroporous calcium phosphate

Pham Trung Kien, Kunio Ishikawa, Kanji Tsuru

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Interconnected macroporous calcium phosphate has attracted attention as an artificial bone substitute as well as a scaffold for tissue engineering. In this investigation, a setting reaction between α-tricalcium phosphate (α-TCP) spheres and an acidic calcium phosphate solution (0.2 mol/L monocalcium phosphate monohydrate – 0.1 mol/L phosphoric acid) was studied to assess the feasibility of fabricating fully interconnected macroporous calcium phosphate. When 1.3 mm-diameter α-TCP spheres were exposed to an acidic calcium phosphate solution, brushite (dicalcium phosphate dihydrate) was formed on the surface of the α-TCP spheres. The precipitated brushite crystals interlocked with one another and bridged the α-TCP spheres, resulting in a 10 min setting reaction at 37 °C that produced fully interconnected macroporous calcium phosphate. The resultant calcium phosphate macroporous structure had a porosity of 49.7±2.5% and an average pore size of 312±160 μm.

Original languageEnglish
Pages (from-to)13525-13531
Number of pages7
JournalCeramics International
Volume41
Issue number10
DOIs
Publication statusPublished - Dec 1 2015

Fingerprint

Calcium phosphate
Fabrication
Phosphates
Bone Substitutes
Phosphoric acid
Scaffolds (biology)
Tissue engineering
Pore size
calcium phosphate
Bone
Porosity
Crystals
dibasic calcium phosphate dihydrate

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Process Chemistry and Technology
  • Surfaces, Coatings and Films
  • Materials Chemistry

Cite this

Setting reaction of α-TCP spheres and an acidic calcium phosphate solution for the fabrication of fully interconnected macroporous calcium phosphate. / Kien, Pham Trung; Ishikawa, Kunio; Tsuru, Kanji.

In: Ceramics International, Vol. 41, No. 10, 01.12.2015, p. 13525-13531.

Research output: Contribution to journalArticle

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