Severe aplastic anemia in a patient with primary immunodeficiency

SHOUICHI OHGA, TAKAKO NAGASHIMA, MARI NISHIZAKI, CHIKAKO HIRABARU, TOSHIROU INOUE, KEIKO ISE, TOSHIRO HARA, KOHJI UEDA

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3 Citations (Scopus)

Abstract

This paper reports the case of a 6 year old boy with primary immunodeficiency disease, whose marrow cells showed dyshematopoietic features, that was subsequently transformed to severe aplastic anemia. He was first diagnosed as having congenital immunodeficiency comprising deficiency of immunoglobulin A (IgA), IgG2 and IgG4, depressed mitogen responses, lymphopenia with inverted CD4/CD8 ratio and an increased proportion of T‐cell receptor γ/δ‐bearing cells. Cytogenetic study of the peripheral blood showed a normal karyotype of 46, XY, but that of the marked hypoplastic marrow demonstrated one cell with monosomy 7 and another with trisomy 8 in the 20 cells examined. 1994 Japan Pediatric Society

Original languageEnglish
Pages (from-to)212-216
Number of pages5
JournalPediatrics International
Volume36
Issue number2
DOIs
Publication statusPublished - Apr 1994

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

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