Severe Infectious Mononucleosis-like Syndrome and Primary Human Herpesvirus 6 Infection in an Adult

Koichi Akashi, Yoshito Eizuru, Yoshiaki Sumiyoshi, Toshio Minematsu, Sachiko Hara, Mine Harada, Masahiro Kikuchi, Yoshiyuki Niho, Yoichi Minamishima

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136 Citations (Scopus)


Human herpesvirus 6 (HHV-6) was first isolated from patients with the acquired immunodeficiency syndrome or lymphoproliferative diseases and was named human B-lymphotropic virus1. However, later studies revealed that the virus is T-lymphotropic in vitro2 and in vivo3. Recently, two genotypes of HHV-6 (type A and type B) have been distinguished on the basis of their restriction polymorphism46. HHV-6 has been identified as the etiologic agent of exanthem subitum in infants,7 and an acute febrile illness in young children8. Most people are seropositive for HHV-6 by the age of three years9,10. HHV-6 also produces…

Original languageEnglish
Pages (from-to)168-171
Number of pages4
JournalNew England Journal of Medicine
Issue number3
Publication statusPublished - Jul 15 1993
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Medicine(all)

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