Severe localized stenosis and marked dilatation of the main pancreatic duct are indicators of pancreatic cancer instead of chronic pancreatitis on endoscopic retrograde balloon pancreatography

Ken Inoue, Jiro Ohuchida, Ohtsuka Takao, Toshinaga Nabae, Kazunori Yokohata, Yoshiaki Ogawa, Koji Yamaguchi, Masao Tanaka

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background: Differentiation between benign and malignant localized stenoses of the main pancreatic duct is difficult by pancreatography. Methods: A total of 48 patients with such localized stenosis who underwent endoscopic retrograde balloon pancreatography with abdominal compression were retrospectively studied. The following were examined: (1) diameter of the stenotic, prestenotic, and poststenotic ductal segments; (2) ratios of prestenotic/poststenotic, stenotic/prestenotic, and stenotic/poststenotic ductal segments; (3) length of stenosis and steepness of transition to the stenosis (proximal angle, distal angle); and (4) main duct and branch findings for peristenotic segments. Results: The stenosis was diagnosed as caused by chronic pancreatitis in 27 patients and pancreatic cancer in 21 by histopathology, cytology, or clinical follow-up. The prestenotic/poststenotic ductal segments ratio and proximal angle were greater in pancreatic cancer compared with chronic pancreatitis. Severe stenosis (stenotic ductal segments less than 20% of prestenotic or poststenotic ductal segments); moderate (prestenotic ductal segments 2.5 to 3.5 times larger than poststenotic ductal segments), and severe (prestenotic ductal segments more than 3.5 times larger than poststenotic ductal segments) dilatation of the proximal duct were more frequent in pancreatic cancer than in chronic pancreatitis. Multivariate regression analyses showed that severe stenosis and dilatation were independently significant parameters that indicated a diagnosis of pancreatic cancer. Various combinations of severe stenosis, proximal dilatation, and double duct sign gave high predictive values. Conclusions: Severe stenosis, marked proximal dilatation, double duct sign, and combinations of these findings are useful indicators of malignant localized stenosis of the pancreatic duct.

Original languageEnglish
Pages (from-to)510-515
Number of pages6
JournalGastrointestinal endoscopy
Volume58
Issue number4
DOIs
Publication statusPublished - Oct 1 2003

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Pancreatic Ducts
Chronic Pancreatitis
Pancreatic Neoplasms
Dilatation
Pathologic Constriction
Cell Biology
Multivariate Analysis
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

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Severe localized stenosis and marked dilatation of the main pancreatic duct are indicators of pancreatic cancer instead of chronic pancreatitis on endoscopic retrograde balloon pancreatography. / Inoue, Ken; Ohuchida, Jiro; Takao, Ohtsuka; Nabae, Toshinaga; Yokohata, Kazunori; Ogawa, Yoshiaki; Yamaguchi, Koji; Tanaka, Masao.

In: Gastrointestinal endoscopy, Vol. 58, No. 4, 01.10.2003, p. 510-515.

Research output: Contribution to journalArticle

Inoue, Ken ; Ohuchida, Jiro ; Takao, Ohtsuka ; Nabae, Toshinaga ; Yokohata, Kazunori ; Ogawa, Yoshiaki ; Yamaguchi, Koji ; Tanaka, Masao. / Severe localized stenosis and marked dilatation of the main pancreatic duct are indicators of pancreatic cancer instead of chronic pancreatitis on endoscopic retrograde balloon pancreatography. In: Gastrointestinal endoscopy. 2003 ; Vol. 58, No. 4. pp. 510-515.
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T1 - Severe localized stenosis and marked dilatation of the main pancreatic duct are indicators of pancreatic cancer instead of chronic pancreatitis on endoscopic retrograde balloon pancreatography

AU - Inoue, Ken

AU - Ohuchida, Jiro

AU - Takao, Ohtsuka

AU - Nabae, Toshinaga

AU - Yokohata, Kazunori

AU - Ogawa, Yoshiaki

AU - Yamaguchi, Koji

AU - Tanaka, Masao

PY - 2003/10/1

Y1 - 2003/10/1

N2 - Background: Differentiation between benign and malignant localized stenoses of the main pancreatic duct is difficult by pancreatography. Methods: A total of 48 patients with such localized stenosis who underwent endoscopic retrograde balloon pancreatography with abdominal compression were retrospectively studied. The following were examined: (1) diameter of the stenotic, prestenotic, and poststenotic ductal segments; (2) ratios of prestenotic/poststenotic, stenotic/prestenotic, and stenotic/poststenotic ductal segments; (3) length of stenosis and steepness of transition to the stenosis (proximal angle, distal angle); and (4) main duct and branch findings for peristenotic segments. Results: The stenosis was diagnosed as caused by chronic pancreatitis in 27 patients and pancreatic cancer in 21 by histopathology, cytology, or clinical follow-up. The prestenotic/poststenotic ductal segments ratio and proximal angle were greater in pancreatic cancer compared with chronic pancreatitis. Severe stenosis (stenotic ductal segments less than 20% of prestenotic or poststenotic ductal segments); moderate (prestenotic ductal segments 2.5 to 3.5 times larger than poststenotic ductal segments), and severe (prestenotic ductal segments more than 3.5 times larger than poststenotic ductal segments) dilatation of the proximal duct were more frequent in pancreatic cancer than in chronic pancreatitis. Multivariate regression analyses showed that severe stenosis and dilatation were independently significant parameters that indicated a diagnosis of pancreatic cancer. Various combinations of severe stenosis, proximal dilatation, and double duct sign gave high predictive values. Conclusions: Severe stenosis, marked proximal dilatation, double duct sign, and combinations of these findings are useful indicators of malignant localized stenosis of the pancreatic duct.

AB - Background: Differentiation between benign and malignant localized stenoses of the main pancreatic duct is difficult by pancreatography. Methods: A total of 48 patients with such localized stenosis who underwent endoscopic retrograde balloon pancreatography with abdominal compression were retrospectively studied. The following were examined: (1) diameter of the stenotic, prestenotic, and poststenotic ductal segments; (2) ratios of prestenotic/poststenotic, stenotic/prestenotic, and stenotic/poststenotic ductal segments; (3) length of stenosis and steepness of transition to the stenosis (proximal angle, distal angle); and (4) main duct and branch findings for peristenotic segments. Results: The stenosis was diagnosed as caused by chronic pancreatitis in 27 patients and pancreatic cancer in 21 by histopathology, cytology, or clinical follow-up. The prestenotic/poststenotic ductal segments ratio and proximal angle were greater in pancreatic cancer compared with chronic pancreatitis. Severe stenosis (stenotic ductal segments less than 20% of prestenotic or poststenotic ductal segments); moderate (prestenotic ductal segments 2.5 to 3.5 times larger than poststenotic ductal segments), and severe (prestenotic ductal segments more than 3.5 times larger than poststenotic ductal segments) dilatation of the proximal duct were more frequent in pancreatic cancer than in chronic pancreatitis. Multivariate regression analyses showed that severe stenosis and dilatation were independently significant parameters that indicated a diagnosis of pancreatic cancer. Various combinations of severe stenosis, proximal dilatation, and double duct sign gave high predictive values. Conclusions: Severe stenosis, marked proximal dilatation, double duct sign, and combinations of these findings are useful indicators of malignant localized stenosis of the pancreatic duct.

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U2 - 10.1067/S0016-5107(03)01962-X

DO - 10.1067/S0016-5107(03)01962-X

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