Severe pulmonary hypertension in a patient with systemic lupus erythematosus and minimal lupus activity

Nobutoshi Kawamura, Hiroyuki Tsutsui, Kae Fukuyama, Shunji Hayashidani, George Koike, Kensuke Egashira, A. B.E. Yasunobu, Hidetaka Yamamoto, Masazumi Tsuneyoshi, Akira Takeshita

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Pulmonary hypertension (PH) sometimes occurs in patients with systemic lupus erythematosus (SLE). We report a case of 51-year-old-woman with PH associated with SLE. She had been diagnosed as SLE on the basis of pericardial effusion, hematological disorder, positive antinuclear antibody, and hypocomplementemia. Despite minimal lupus activity, she had marked elevation of pulmonary arterial pressure (101/53 mmHg) and decreased cardiac index (1.5 l/min/m2). Symptoms related to PH were progressive under treatment with oral corticosteroids, oxygen, calcium antagonists, and warfarin. After 17 months of epoprostenol treatment, she died of pulmonary infarction. SLE-associated PH is often severe and progressive even in association with minimal activity.

Original languageEnglish
Pages (from-to)109-112
Number of pages4
JournalInternal Medicine
Volume41
Issue number2
DOIs
Publication statusPublished - 2002

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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