Severe pulmonary hypertension in a patient with systemic lupus erythematosus and minimal lupus activity

Nobutoshi Kawamura; Hiroyuki Tsutsui; Kae Fukuyama; Shunji Hayashidani; George Koike; Kensuke Egashira; A. B.E. Yasunobu; Hidetaka Yamamoto; Masazumi Tsuneyoshi; Akira Takeshita

doi:10.2169/internalmedicine.41.109

Severe pulmonary hypertension in a patient with systemic lupus erythematosus and minimal lupus activity

Nobutoshi Kawamura, Hiroyuki Tsutsui, Kae Fukuyama, Shunji Hayashidani, George Koike, Kensuke Egashira, A. B.E. Yasunobu, Hidetaka Yamamoto, Masazumi Tsuneyoshi, Akira Takeshita

Division of Diagnostic Pathology

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Pulmonary hypertension (PH) sometimes occurs in patients with systemic lupus erythematosus (SLE). We report a case of 51-year-old-woman with PH associated with SLE. She had been diagnosed as SLE on the basis of pericardial effusion, hematological disorder, positive antinuclear antibody, and hypocomplementemia. Despite minimal lupus activity, she had marked elevation of pulmonary arterial pressure (101/53 mmHg) and decreased cardiac index (1.5 l/min/m²). Symptoms related to PH were progressive under treatment with oral corticosteroids, oxygen, calcium antagonists, and warfarin. After 17 months of epoprostenol treatment, she died of pulmonary infarction. SLE-associated PH is often severe and progressive even in association with minimal activity.

Original language	English
Pages (from-to)	109-112
Number of pages	4
Journal	Internal Medicine
Volume	41
Issue number	2
DOIs	https://doi.org/10.2169/internalmedicine.41.109
Publication status	Published - 2002

All Science Journal Classification (ASJC) codes

Internal Medicine

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10.2169/internalmedicine.41.109

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title = "Severe pulmonary hypertension in a patient with systemic lupus erythematosus and minimal lupus activity",

abstract = "Pulmonary hypertension (PH) sometimes occurs in patients with systemic lupus erythematosus (SLE). We report a case of 51-year-old-woman with PH associated with SLE. She had been diagnosed as SLE on the basis of pericardial effusion, hematological disorder, positive antinuclear antibody, and hypocomplementemia. Despite minimal lupus activity, she had marked elevation of pulmonary arterial pressure (101/53 mmHg) and decreased cardiac index (1.5 l/min/m2). Symptoms related to PH were progressive under treatment with oral corticosteroids, oxygen, calcium antagonists, and warfarin. After 17 months of epoprostenol treatment, she died of pulmonary infarction. SLE-associated PH is often severe and progressive even in association with minimal activity.",

author = "Nobutoshi Kawamura and Hiroyuki Tsutsui and Kae Fukuyama and Shunji Hayashidani and George Koike and Kensuke Egashira and Yasunobu, {A. B.E.} and Hidetaka Yamamoto and Masazumi Tsuneyoshi and Akira Takeshita",

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doi = "10.2169/internalmedicine.41.109",

language = "English",

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TY - JOUR

T1 - Severe pulmonary hypertension in a patient with systemic lupus erythematosus and minimal lupus activity

AU - Kawamura, Nobutoshi

AU - Tsutsui, Hiroyuki

AU - Fukuyama, Kae

AU - Hayashidani, Shunji

AU - Koike, George

AU - Egashira, Kensuke

AU - Yasunobu, A. B.E.

AU - Yamamoto, Hidetaka

AU - Tsuneyoshi, Masazumi

AU - Takeshita, Akira

PY - 2002

Y1 - 2002

N2 - Pulmonary hypertension (PH) sometimes occurs in patients with systemic lupus erythematosus (SLE). We report a case of 51-year-old-woman with PH associated with SLE. She had been diagnosed as SLE on the basis of pericardial effusion, hematological disorder, positive antinuclear antibody, and hypocomplementemia. Despite minimal lupus activity, she had marked elevation of pulmonary arterial pressure (101/53 mmHg) and decreased cardiac index (1.5 l/min/m2). Symptoms related to PH were progressive under treatment with oral corticosteroids, oxygen, calcium antagonists, and warfarin. After 17 months of epoprostenol treatment, she died of pulmonary infarction. SLE-associated PH is often severe and progressive even in association with minimal activity.

AB - Pulmonary hypertension (PH) sometimes occurs in patients with systemic lupus erythematosus (SLE). We report a case of 51-year-old-woman with PH associated with SLE. She had been diagnosed as SLE on the basis of pericardial effusion, hematological disorder, positive antinuclear antibody, and hypocomplementemia. Despite minimal lupus activity, she had marked elevation of pulmonary arterial pressure (101/53 mmHg) and decreased cardiac index (1.5 l/min/m2). Symptoms related to PH were progressive under treatment with oral corticosteroids, oxygen, calcium antagonists, and warfarin. After 17 months of epoprostenol treatment, she died of pulmonary infarction. SLE-associated PH is often severe and progressive even in association with minimal activity.

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EP - 112

JO - Internal Medicine

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Severe pulmonary hypertension in a patient with systemic lupus erythematosus and minimal lupus activity

Abstract

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