Severity of oral mucositis correlates with the response of oral cancer to preoperative radiochemotherapy

Tetsuro Ikebe, K. Seki, S. Nakamura, Y. Takenoshita, H. Nakayama, M. Shinohara, K. Shirasuna

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3 Citations (Scopus)

Abstract

Oral mucositis is a dose-limiting toxic effect of radiotherapy and chemotherapy on oral cancer. The purpose of the present study is to assess the relationship between tumor response and oral mucositis in preoperative radiochemotherapy for oral cancer retrospectively. Fifty-four cases of oral squamous cell carcinoma were treated with concurrent radiochemotherapy prior to surgery. When oral mucositis was evaluated with the WHO scale, severe oral mucositis (Grades 3 and 4) developed in 22 cases (41%). A more than 50% reduction in tumor size was clinically observed in 38 cases (70%). From histopathological analysis of the surgical specimens all tumor cells observed appeared to be non-viable in 16 cases (29%). The cases with Grade 1, Grade 2, Grade 3 and Grade 4 oral mucositis included 33%, 62%, 85% and 89% of clinical good-response cases and 0%, 24%, 31% and 55% of histopathological good-response cases, respectively. This retrospective study suggests that severe oral mucositis promises a good response of oral squamous cell carcinoma to radiochemotherapy.

Original languageEnglish
Pages (from-to)642-645
Number of pages4
JournalInternational Journal of Oral and Maxillofacial Surgery
Volume34
Issue number6
DOIs
Publication statusPublished - Sep 1 2005

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Stomatitis
Mouth Neoplasms
Chemoradiotherapy
Squamous Cell Carcinoma
Neoplasms
Poisons
Radiotherapy
Retrospective Studies
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

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Severity of oral mucositis correlates with the response of oral cancer to preoperative radiochemotherapy. / Ikebe, Tetsuro; Seki, K.; Nakamura, S.; Takenoshita, Y.; Nakayama, H.; Shinohara, M.; Shirasuna, K.

In: International Journal of Oral and Maxillofacial Surgery, Vol. 34, No. 6, 01.09.2005, p. 642-645.

Research output: Contribution to journalArticle

Ikebe, Tetsuro ; Seki, K. ; Nakamura, S. ; Takenoshita, Y. ; Nakayama, H. ; Shinohara, M. ; Shirasuna, K. / Severity of oral mucositis correlates with the response of oral cancer to preoperative radiochemotherapy. In: International Journal of Oral and Maxillofacial Surgery. 2005 ; Vol. 34, No. 6. pp. 642-645.
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