Sex differences in the association between serum uric acid levels and cardiac hypertrophy in patients with chronic kidney disease

Ryota Yoshitomi, Akiko Fukui, Masaru Nakayama, Yoriko Ura, Hirofumi Ikeda, Hideyuki Oniki, Takuya Tsuchihashi, Kazuhiko Tsuruya, Takanari Kitazono

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Several studies have documented an association between serum uric acid (SUA) concentration and cardiac hypertrophy in hypertensive patients; however, the association remains unclear in chronic kidney disease (CKD) patients. If there is an association between SUA and hypertrophy in these patients, it is unknown whether the association is different between men and women. Our aim in this study is to determine whether SUA is associated with cardiac hypertrophy in CKD patients, focusing on any sex differences. Two hundred sixteen CKD patients (117 men and 99 women) were enrolled in this cross-sectional study. Patients prescribed uric acid-lowering agents and those with congestive heart failure, valvular heart disease, or ischemic heart disease were excluded from this study. Left ventricular mass index (LVMI) and left ventricular hypertrophy (LVH) were assessed using echocardiography. The prevalence of LVH was 58% in men and 47% in women. In multivariate linear regression analysis, SUA levels did not correlate with LVMI in men, whereas SUA was independently associated with LVMI in women (β=0.27, P=0.02). Multivariate logistic regression analysis also revealed that diabetes mellitus (odds ratio (OR), 4.41; P=0.01) was associated with LVH in men, whereas age (OR, 1.13; P<0.01), hypertension (OR, 7.38; P=0.03) and SUA (OR, 1.91; P=0.03) were associated with LVH in women. In female CKD patients, SUA levels were associated with LVMI and LVH, whereas there was no association in male patients. These observations suggest that an association between SUA levels and the development of cardiac hypertrophy is more likely in women than in men.

Original languageEnglish
Pages (from-to)246-252
Number of pages7
JournalHypertension Research
Volume37
Issue number3
DOIs
Publication statusPublished - Jan 1 2014

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Cardiomegaly
Uric Acid
Chronic Renal Insufficiency
Sex Characteristics
Left Ventricular Hypertrophy
Serum
Odds Ratio
Regression Analysis
Heart Valve Diseases
Hypertrophy
Myocardial Ischemia
Echocardiography
Linear Models
Diabetes Mellitus
Heart Failure
Cross-Sectional Studies
Logistic Models
Hypertension

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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Sex differences in the association between serum uric acid levels and cardiac hypertrophy in patients with chronic kidney disease. / Yoshitomi, Ryota; Fukui, Akiko; Nakayama, Masaru; Ura, Yoriko; Ikeda, Hirofumi; Oniki, Hideyuki; Tsuchihashi, Takuya; Tsuruya, Kazuhiko; Kitazono, Takanari.

In: Hypertension Research, Vol. 37, No. 3, 01.01.2014, p. 246-252.

Research output: Contribution to journalArticle

Yoshitomi, R, Fukui, A, Nakayama, M, Ura, Y, Ikeda, H, Oniki, H, Tsuchihashi, T, Tsuruya, K & Kitazono, T 2014, 'Sex differences in the association between serum uric acid levels and cardiac hypertrophy in patients with chronic kidney disease', Hypertension Research, vol. 37, no. 3, pp. 246-252. https://doi.org/10.1038/hr.2013.134
Yoshitomi, Ryota ; Fukui, Akiko ; Nakayama, Masaru ; Ura, Yoriko ; Ikeda, Hirofumi ; Oniki, Hideyuki ; Tsuchihashi, Takuya ; Tsuruya, Kazuhiko ; Kitazono, Takanari. / Sex differences in the association between serum uric acid levels and cardiac hypertrophy in patients with chronic kidney disease. In: Hypertension Research. 2014 ; Vol. 37, No. 3. pp. 246-252.
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