Sex-related differences in the muscarinic acetylcholinergic receptor in the healthy human brain - A positron emission tomography study

Tsuyoshi Yoshida, Yasuo Kuwabara, Masayuki Sasaki, Toshimitsu Fukumura, Atsushi Ichimiya, Masashi Takita, Koji Ogomori, Yuichi Ichiya, Kouji Masuda

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We evaluated the sex-related differences in the decline of the cerebral muscarinic acetylcholinergic receptor (mACh-R) due to aging by using 11C-N- methyl-4-piperidyl benzilate (11C-NMPB) and positron emission tomography (PET). The subjects consisted of 37 (20 males and 17 females) healthy volunteers. The 11C-NMPB uptake was evaluated by the ratio method (regional 11C-NMPB uptake/Cerebellar 11C-NMPB uptake; rNMPB ratio). The correlation between sex, aging, and the rNMPB ratio in normal aging was evaluated by a multiple regression analysis. The rNMPB ratio was higher in females than in males throughout the entire cerebral region (p < 0.01-p < 0.0001) and the rNMPB ratio might thus possibly decline with age more rapidly in females. Our study therefore revealed the existence of sex-related differences in the cerebral mACh-R.

Original languageEnglish
Pages (from-to)97-101
Number of pages5
JournalAnnals of Nuclear Medicine
Issue number2
Publication statusPublished - Apr 2000


All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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