Sex-related differences in the muscarinic acetylcholinergic receptor in the healthy human brain - A positron emission tomography study

Tsuyoshi Yoshida; Yasuo Kuwabara; Masayuki Sasaki; Toshimitsu Fukumura; Atsushi Ichimiya; Masashi Takita; Koji Ogomori; Yuichi Ichiya; Kouji Masuda

doi:10.1007/BF02988587

Sex-related differences in the muscarinic acetylcholinergic receptor in the healthy human brain - A positron emission tomography study

Tsuyoshi Yoshida, Yasuo Kuwabara, Masayuki Sasaki, Toshimitsu Fukumura, Atsushi Ichimiya, Masashi Takita, Koji Ogomori, Yuichi Ichiya, Kouji Masuda

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

We evaluated the sex-related differences in the decline of the cerebral muscarinic acetylcholinergic receptor (mACh-R) due to aging by using ¹¹C-N- methyl-4-piperidyl benzilate (¹¹C-NMPB) and positron emission tomography (PET). The subjects consisted of 37 (20 males and 17 females) healthy volunteers. The ¹¹C-NMPB uptake was evaluated by the ratio method (regional ¹¹C-NMPB uptake/Cerebellar ¹¹C-NMPB uptake; rNMPB ratio). The correlation between sex, aging, and the rNMPB ratio in normal aging was evaluated by a multiple regression analysis. The rNMPB ratio was higher in females than in males throughout the entire cerebral region (p < 0.01-p < 0.0001) and the rNMPB ratio might thus possibly decline with age more rapidly in females. Our study therefore revealed the existence of sex-related differences in the cerebral mACh-R.

Original language	English
Pages (from-to)	97-101
Number of pages	5
Journal	Annals of Nuclear Medicine
Volume	14
Issue number	2
DOIs	https://doi.org/10.1007/BF02988587
Publication status	Published - Apr 2000

All Science Journal Classification (ASJC) codes

Radiology Nuclear Medicine and imaging

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10.1007/BF02988587

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Sex-related differences in the muscarinic acetylcholinergic receptor in the healthy human brain - A positron emission tomography study. / Yoshida, Tsuyoshi; Kuwabara, Yasuo; Sasaki, Masayuki; Fukumura, Toshimitsu; Ichimiya, Atsushi; Takita, Masashi; Ogomori, Koji; Ichiya, Yuichi; Masuda, Kouji.

In: Annals of Nuclear Medicine, Vol. 14, No. 2, 04.2000, p. 97-101.

Research output: Contribution to journal › Article › peer-review

Yoshida, Tsuyoshi ; Kuwabara, Yasuo ; Sasaki, Masayuki ; Fukumura, Toshimitsu ; Ichimiya, Atsushi ; Takita, Masashi ; Ogomori, Koji ; Ichiya, Yuichi ; Masuda, Kouji. / Sex-related differences in the muscarinic acetylcholinergic receptor in the healthy human brain - A positron emission tomography study. In: Annals of Nuclear Medicine. 2000 ; Vol. 14, No. 2. pp. 97-101.

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abstract = "We evaluated the sex-related differences in the decline of the cerebral muscarinic acetylcholinergic receptor (mACh-R) due to aging by using 11C-N- methyl-4-piperidyl benzilate (11C-NMPB) and positron emission tomography (PET). The subjects consisted of 37 (20 males and 17 females) healthy volunteers. The 11C-NMPB uptake was evaluated by the ratio method (regional 11C-NMPB uptake/Cerebellar 11C-NMPB uptake; rNMPB ratio). The correlation between sex, aging, and the rNMPB ratio in normal aging was evaluated by a multiple regression analysis. The rNMPB ratio was higher in females than in males throughout the entire cerebral region (p < 0.01-p < 0.0001) and the rNMPB ratio might thus possibly decline with age more rapidly in females. Our study therefore revealed the existence of sex-related differences in the cerebral mACh-R.",

author = "Tsuyoshi Yoshida and Yasuo Kuwabara and Masayuki Sasaki and Toshimitsu Fukumura and Atsushi Ichimiya and Masashi Takita and Koji Ogomori and Yuichi Ichiya and Kouji Masuda",

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