Sex-related differences in the muscarinic acetylcholinergic receptor in the healthy human brain - A positron emission tomography study

Tsuyoshi Yoshida; Yasuo Kuwabara; Masayuki Sasaki; Toshimitsu Fukumura; Atsushi Ichimiya; Masashi Takita; Koji Ogomori; Yuichi Ichiya; Kouji Masuda

doi:10.1007/BF02988587

Sex-related differences in the muscarinic acetylcholinergic receptor in the healthy human brain - A positron emission tomography study

Tsuyoshi Yoshida, Yasuo Kuwabara, Masayuki Sasaki, Toshimitsu Fukumura, Atsushi Ichimiya, Masashi Takita, Koji Ogomori, Yuichi Ichiya, Kouji Masuda

Division of medical Quantum Science

Research output: Contribution to journal › Article › peer-review

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Abstract

We evaluated the sex-related differences in the decline of the cerebral muscarinic acetylcholinergic receptor (mACh-R) due to aging by using ¹¹C-N- methyl-4-piperidyl benzilate (¹¹C-NMPB) and positron emission tomography (PET). The subjects consisted of 37 (20 males and 17 females) healthy volunteers. The ¹¹C-NMPB uptake was evaluated by the ratio method (regional ¹¹C-NMPB uptake/Cerebellar ¹¹C-NMPB uptake; rNMPB ratio). The correlation between sex, aging, and the rNMPB ratio in normal aging was evaluated by a multiple regression analysis. The rNMPB ratio was higher in females than in males throughout the entire cerebral region (p < 0.01-p < 0.0001) and the rNMPB ratio might thus possibly decline with age more rapidly in females. Our study therefore revealed the existence of sex-related differences in the cerebral mACh-R.

Original language	English
Pages (from-to)	97-101
Number of pages	5
Journal	Annals of Nuclear Medicine
Volume	14
Issue number	2
DOIs	https://doi.org/10.1007/BF02988587
Publication status	Published - Apr 2000

All Science Journal Classification (ASJC) codes

Radiology Nuclear Medicine and imaging

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF02988587

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@article{64ebbf404a7d47848d8f1deec8907843,

title = "Sex-related differences in the muscarinic acetylcholinergic receptor in the healthy human brain - A positron emission tomography study",

abstract = "We evaluated the sex-related differences in the decline of the cerebral muscarinic acetylcholinergic receptor (mACh-R) due to aging by using 11C-N- methyl-4-piperidyl benzilate (11C-NMPB) and positron emission tomography (PET). The subjects consisted of 37 (20 males and 17 females) healthy volunteers. The 11C-NMPB uptake was evaluated by the ratio method (regional 11C-NMPB uptake/Cerebellar 11C-NMPB uptake; rNMPB ratio). The correlation between sex, aging, and the rNMPB ratio in normal aging was evaluated by a multiple regression analysis. The rNMPB ratio was higher in females than in males throughout the entire cerebral region (p < 0.01-p < 0.0001) and the rNMPB ratio might thus possibly decline with age more rapidly in females. Our study therefore revealed the existence of sex-related differences in the cerebral mACh-R.",

author = "Tsuyoshi Yoshida and Yasuo Kuwabara and Masayuki Sasaki and Toshimitsu Fukumura and Atsushi Ichimiya and Masashi Takita and Koji Ogomori and Yuichi Ichiya and Kouji Masuda",

note = "Funding Information: The authors thank Dr. Osamu l noue of Osaka University and Dr. Kazutoshi Suzuki of the National Institute of Radiological Sciences for their pharmaceutical advice and we also thank Assist. Professor Hiroyoshi Toyoshiba of Department of Medical lnformatic for statistical advice and Dr. Brian T. Quinn of Kyushu University for editorial assistance. This work was partly supported by Grant No. 6B-2 and a No. 94A-2401-4 from the Japanese Ministry of Health and Welfare, and a Grant-in-Aid (05670781) for Scientific Research from the Japanese Ministry of Education, Science and Culture.",

year = "2000",

month = apr,

doi = "10.1007/BF02988587",

language = "English",

volume = "14",

pages = "97--101",

journal = "Annals of Nuclear Medicine",

issn = "0914-7187",

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T1 - Sex-related differences in the muscarinic acetylcholinergic receptor in the healthy human brain - A positron emission tomography study

AU - Yoshida, Tsuyoshi

AU - Kuwabara, Yasuo

AU - Sasaki, Masayuki

AU - Fukumura, Toshimitsu

AU - Ichimiya, Atsushi

AU - Takita, Masashi

AU - Ogomori, Koji

AU - Ichiya, Yuichi

AU - Masuda, Kouji

N1 - Funding Information: The authors thank Dr. Osamu l noue of Osaka University and Dr. Kazutoshi Suzuki of the National Institute of Radiological Sciences for their pharmaceutical advice and we also thank Assist. Professor Hiroyoshi Toyoshiba of Department of Medical lnformatic for statistical advice and Dr. Brian T. Quinn of Kyushu University for editorial assistance. This work was partly supported by Grant No. 6B-2 and a No. 94A-2401-4 from the Japanese Ministry of Health and Welfare, and a Grant-in-Aid (05670781) for Scientific Research from the Japanese Ministry of Education, Science and Culture.

PY - 2000/4

Y1 - 2000/4

N2 - We evaluated the sex-related differences in the decline of the cerebral muscarinic acetylcholinergic receptor (mACh-R) due to aging by using 11C-N- methyl-4-piperidyl benzilate (11C-NMPB) and positron emission tomography (PET). The subjects consisted of 37 (20 males and 17 females) healthy volunteers. The 11C-NMPB uptake was evaluated by the ratio method (regional 11C-NMPB uptake/Cerebellar 11C-NMPB uptake; rNMPB ratio). The correlation between sex, aging, and the rNMPB ratio in normal aging was evaluated by a multiple regression analysis. The rNMPB ratio was higher in females than in males throughout the entire cerebral region (p < 0.01-p < 0.0001) and the rNMPB ratio might thus possibly decline with age more rapidly in females. Our study therefore revealed the existence of sex-related differences in the cerebral mACh-R.

AB - We evaluated the sex-related differences in the decline of the cerebral muscarinic acetylcholinergic receptor (mACh-R) due to aging by using 11C-N- methyl-4-piperidyl benzilate (11C-NMPB) and positron emission tomography (PET). The subjects consisted of 37 (20 males and 17 females) healthy volunteers. The 11C-NMPB uptake was evaluated by the ratio method (regional 11C-NMPB uptake/Cerebellar 11C-NMPB uptake; rNMPB ratio). The correlation between sex, aging, and the rNMPB ratio in normal aging was evaluated by a multiple regression analysis. The rNMPB ratio was higher in females than in males throughout the entire cerebral region (p < 0.01-p < 0.0001) and the rNMPB ratio might thus possibly decline with age more rapidly in females. Our study therefore revealed the existence of sex-related differences in the cerebral mACh-R.

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Sex-related differences in the muscarinic acetylcholinergic receptor in the healthy human brain - A positron emission tomography study

Abstract

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