Sex specific X chromosome expression caused by genomic imprinting

Y. Iwasa, A. Pomiankowski

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

The conflict theory of genomic imprinting predicts that imprinted genes are growth enhancing when paternally expressed and growth suppressing when maternally expressed. The expression pattern of autosomal imprinted genes generally fits these predictions. However, the conflict theory cannot easily account for the pattern of X-linked imprinting in humans and mice. This has led us to propose a novel hypothesis that X-linked imprinting has evolved to control sex specific gene expression in early embryos. The hypothesis links paternal X-imprinting (i.e. paternal copy silencing) to random X-inactivation and the retention of Y-linked copies, and links maternal X-imprinting to escape from random X-inactivation and the loss of Y-linked copies. The hypothesis offers a good explanation of the existing data on X-imprinted genes.

Original languageEnglish
Pages (from-to)487-495
Number of pages9
JournalJournal of Theoretical Biology
Volume197
Issue number4
DOIs
Publication statusPublished - Apr 21 1999

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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