TY - JOUR
T1 - SF-1 expression during adrenal development and tumourigenesis
AU - Gardiner, Jennifer R.
AU - Shima, Yuichi
AU - Morohashi, Ken ichirou
AU - Swain, Amanda
PY - 2012/3/31
Y1 - 2012/3/31
N2 - SF-1 is a master regulator of steroidogenesis whose expression is critical for normal adrenal and gonadal organogenesis. Strict maintenance of SF-1 levels is essential, and mutations causing under- or overexpression result in congenital adrenal and gonadal defects or hyperplasia, respectively. Data from transgenic mouse models points to a network of transcription factors responsible for stringent regulation of . Sf-1 expression during development, which bind to intronic enhancer elements in addition to the basal promoter to specifically modulate transcription in each . Sf-1-expressing tissue. Furthermore, analysis of the role of SF-1 in adrenal tumourigenesis implies that improper developmental regulation of . Sf-1 expression may have postnatal consequences separate from the well-documented developmental defects.
AB - SF-1 is a master regulator of steroidogenesis whose expression is critical for normal adrenal and gonadal organogenesis. Strict maintenance of SF-1 levels is essential, and mutations causing under- or overexpression result in congenital adrenal and gonadal defects or hyperplasia, respectively. Data from transgenic mouse models points to a network of transcription factors responsible for stringent regulation of . Sf-1 expression during development, which bind to intronic enhancer elements in addition to the basal promoter to specifically modulate transcription in each . Sf-1-expressing tissue. Furthermore, analysis of the role of SF-1 in adrenal tumourigenesis implies that improper developmental regulation of . Sf-1 expression may have postnatal consequences separate from the well-documented developmental defects.
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U2 - 10.1016/j.mce.2011.10.007
DO - 10.1016/j.mce.2011.10.007
M3 - Review article
C2 - 22024498
AN - SCOPUS:84857108757
VL - 351
SP - 12
EP - 18
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
SN - 0303-7207
IS - 1
ER -