SF-1 expression during adrenal development and tumourigenesis

Jennifer R. Gardiner, Yuichi Shima, Ken ichirou Morohashi, Amanda Swain

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)

Abstract

SF-1 is a master regulator of steroidogenesis whose expression is critical for normal adrenal and gonadal organogenesis. Strict maintenance of SF-1 levels is essential, and mutations causing under- or overexpression result in congenital adrenal and gonadal defects or hyperplasia, respectively. Data from transgenic mouse models points to a network of transcription factors responsible for stringent regulation of . Sf-1 expression during development, which bind to intronic enhancer elements in addition to the basal promoter to specifically modulate transcription in each . Sf-1-expressing tissue. Furthermore, analysis of the role of SF-1 in adrenal tumourigenesis implies that improper developmental regulation of . Sf-1 expression may have postnatal consequences separate from the well-documented developmental defects.

Original languageEnglish
Pages (from-to)12-18
Number of pages7
JournalMolecular and Cellular Endocrinology
Volume351
Issue number1
DOIs
Publication statusPublished - Mar 31 2012

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Endocrinology

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