Shared and distinct functions of RAGS and ELF-1 in guiding retinal axons

Bruno Monschau, Claus Kremoser, Kunimasa Ohta, Hideaki Tanaka, Tomomi Kaneko, Tomoko Yamada, Claudia Handwerker, Martin R. Hornberger, Jürgen Löschinger, Elena B. Pasquale, Doyle A. Siever, Michael F. Verderame, Bernhard K. Müller, Friedrich Bonhoeffer, Uwe Drescher

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Abstract

Two ligands for Eph-related receptor tyrosine kinases, RAGS and ELF-1, have been implicated in the control of development of the retinotectal projection. Both molecules are expressed in overlapping gradients in the tectum, the target area of retinal ganglion cell axons. In two in vitro assays ELF-1 is shown to have a repellent axon guidance function for temporal, but apparently not for nasal axons. RAGS on the other hand is repellent for both types of axons, though to different degrees. Thus, RAGS and ELF-1 share some and differ in other properties. The biological activities of these molecules correlate with the strength of interaction with their receptors expressed on RGC axons. The meaning of these findings for guidance of retinal axons in the tectum is discussed.

Original languageEnglish
Pages (from-to)1258-1267
Number of pages10
JournalEMBO Journal
Volume16
Issue number6
DOIs
Publication statusPublished - Mar 17 1997

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All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Monschau, B., Kremoser, C., Ohta, K., Tanaka, H., Kaneko, T., Yamada, T., ... Drescher, U. (1997). Shared and distinct functions of RAGS and ELF-1 in guiding retinal axons. EMBO Journal, 16(6), 1258-1267. https://doi.org/10.1093/emboj/16.6.1258