Shedding light on inflammatory pseudotumor in children: spotlight on inflammatory myofibroblastic tumor

Lillian M. Lai, M. Beth McCarville, Patricia Kirby, Simon C.S. Kao, Toshio Moritani, Eve Clark, Kousei Ishigami, Armita Bahrami, Yutaka Sato

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Inflammatory pseudotumor is a generic term used to designate a heterogeneous group of inflammatory mass-forming lesions histologically characterized by myofibroblastic proliferation with chronic inflammatory infiltrate. Inflammatory pseudotumor is multifactorial in etiology and generally benign, but it is often mistaken for malignancy given its aggressive appearance. It can occur throughout the body and is seen in all age groups. Inflammatory pseudotumor has been described in the literature by many organ-specific names, resulting in confusion. Recently within this generic category of inflammatory pseudotumor, inflammatory myofibroblastic tumor has emerged as a distinct entity and is now recognized as a fibroblastic/myofibroblastic neoplasm with intermediate biological potential and occurring mostly in children. We present interesting pediatric cases of inflammatory myofibroblastic tumors given this entity’s tendency to occur in children. Familiarity and knowledge of the imaging features of inflammatory pseudotumor can help in making an accurate diagnosis, thereby avoiding unnecessary radical surgery.

Original languageEnglish
Pages (from-to)1738-1752
Number of pages15
JournalPediatric Radiology
Volume45
Issue number12
DOIs
Publication statusPublished - Nov 1 2015

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All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Radiology Nuclear Medicine and imaging

Cite this

Lai, L. M., McCarville, M. B., Kirby, P., Kao, S. C. S., Moritani, T., Clark, E., ... Sato, Y. (2015). Shedding light on inflammatory pseudotumor in children: spotlight on inflammatory myofibroblastic tumor. Pediatric Radiology, 45(12), 1738-1752. https://doi.org/10.1007/s00247-015-3360-6