Short poly-glutamine repeat in the androgen receptor in New World monkeys

Chihiro Hiramatsu, Annika Paukner, Hika Kuroshima, Kazuo Fujita, Stephen J. Suomi, Miho Inoue-Murayama

Research output: Contribution to journalArticle

Abstract

The androgen receptor mediates various physiological and developmental functions and is highly conserved in mammals. Although great intraspecific length polymorphisms in poly glutamine (poly-Q) and poly glycine (poly-G) regions of the androgen receptor in humans, apes and several Old World monkeys have been reported, little is known about the characteristics of these regions in New World monkeys. In this study, we surveyed 17 species of New World monkeys and found length polymorphisms in these regions in three species (common squirrel monkeys, tufted capuchin monkeys and owl monkeys). We found that the poly-Q region in New World monkeys is relatively shorter than that in catarrhines (humans, apes and Old World monkeys). In addition, we observed that codon usage for poly-G region in New World monkeys is unique among primates. These results suggest that the length of polymorphic regions in androgen receptor genes have evolved uniquely in New World monkeys.

Original languageEnglish
Pages (from-to)105-113
Number of pages9
JournalMeta Gene
Volume14
DOIs
Publication statusPublished - Dec 1 2017

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Platyrrhini
Androgen Receptors
Cercopithecidae
Hominidae
Glycine
Aotidae
Cebus
Saimiri
Codon
Primates
Mammals
polyglutamine
Genes

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Hiramatsu, C., Paukner, A., Kuroshima, H., Fujita, K., Suomi, S. J., & Inoue-Murayama, M. (2017). Short poly-glutamine repeat in the androgen receptor in New World monkeys. Meta Gene, 14, 105-113. https://doi.org/10.1016/j.mgene.2017.08.006

Short poly-glutamine repeat in the androgen receptor in New World monkeys. / Hiramatsu, Chihiro; Paukner, Annika; Kuroshima, Hika; Fujita, Kazuo; Suomi, Stephen J.; Inoue-Murayama, Miho.

In: Meta Gene, Vol. 14, 01.12.2017, p. 105-113.

Research output: Contribution to journalArticle

Hiramatsu, C, Paukner, A, Kuroshima, H, Fujita, K, Suomi, SJ & Inoue-Murayama, M 2017, 'Short poly-glutamine repeat in the androgen receptor in New World monkeys', Meta Gene, vol. 14, pp. 105-113. https://doi.org/10.1016/j.mgene.2017.08.006
Hiramatsu C, Paukner A, Kuroshima H, Fujita K, Suomi SJ, Inoue-Murayama M. Short poly-glutamine repeat in the androgen receptor in New World monkeys. Meta Gene. 2017 Dec 1;14:105-113. https://doi.org/10.1016/j.mgene.2017.08.006
Hiramatsu, Chihiro ; Paukner, Annika ; Kuroshima, Hika ; Fujita, Kazuo ; Suomi, Stephen J. ; Inoue-Murayama, Miho. / Short poly-glutamine repeat in the androgen receptor in New World monkeys. In: Meta Gene. 2017 ; Vol. 14. pp. 105-113.
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