Short synthesis of (+)-cylindricine C by using a catalytic asymmetric Michael reaction with a two-center organocatalyst

Tomoyuki Shibuguchi, Hisashi Mihara, Akiyoshi Kuramochi, Shun Sakuraba, Takashi Ohshima, Masakatsu Shibasaki

Research output: Contribution to journalArticlepeer-review

77 Citations (Scopus)

Abstract

(Chemical Equation Presented) Two for the price of one: The total synthesis of (+)-cylindricine C has been achieved in six steps using a catalytic asymmetric Michael reaction and tandem cyclization. A newly designed two-center organocatalyst gives good selectivity in this Michael reaction. TaDiAS = tartrate-derived diammonium salt.

Original languageEnglish
Pages (from-to)4635-4637
Number of pages3
JournalAngewandte Chemie - International Edition
Volume45
Issue number28
DOIs
Publication statusPublished - Jul 10 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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