Sick sinus syndrome observed in a patient with cholinesterase deficiency

Shioto Yasuda, Mitsuhiro Fukata, Taku Yokoyama, Takeshi Arita, Keita Odashiro, Toru Maruyama, Yoichiro Hiramoto, Koichi Akashi

Research output: Contribution to journalArticle

Abstract

A 58-year-old woman complained of general fatigue and was diagnosed with sick sinus syndrome (SSS) by ambulatory electrocardiogram, which demonstrated sinus arrest at midnight and paroxysmal atrial fibrillation (AF) at nighttime. Since her plasma cholinesterase (ChE) activity had been persistently zero, she was diagnosed with ChE deficiency. She refused permanent pacemaker implantation, and treatment with positive chronotropic drugs is ongoing. A novel association of ChE deficiency with SSS is theoretically possible rather than coincident, considering that ChE plays a key role in cholinergic influences on the sinus node leading to sinus bradyarrhythmia and on the atria, causing vagally mediated AF.

Original languageEnglish
Pages (from-to)809-812
Number of pages4
JournalInternal Medicine
Volume58
Issue number6
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Sick Sinus Syndrome
Cholinesterases
Atrial Fibrillation
Sinoatrial Node
Bradycardia
Cholinergic Agents
Fatigue
Electrocardiography
Pharmaceutical Preparations
Therapeutics

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Sick sinus syndrome observed in a patient with cholinesterase deficiency. / Yasuda, Shioto; Fukata, Mitsuhiro; Yokoyama, Taku; Arita, Takeshi; Odashiro, Keita; Maruyama, Toru; Hiramoto, Yoichiro; Akashi, Koichi.

In: Internal Medicine, Vol. 58, No. 6, 01.01.2019, p. 809-812.

Research output: Contribution to journalArticle

Yasuda, Shioto ; Fukata, Mitsuhiro ; Yokoyama, Taku ; Arita, Takeshi ; Odashiro, Keita ; Maruyama, Toru ; Hiramoto, Yoichiro ; Akashi, Koichi. / Sick sinus syndrome observed in a patient with cholinesterase deficiency. In: Internal Medicine. 2019 ; Vol. 58, No. 6. pp. 809-812.
@article{96c2147064e7444aab15780879fe7e23,
title = "Sick sinus syndrome observed in a patient with cholinesterase deficiency",
abstract = "A 58-year-old woman complained of general fatigue and was diagnosed with sick sinus syndrome (SSS) by ambulatory electrocardiogram, which demonstrated sinus arrest at midnight and paroxysmal atrial fibrillation (AF) at nighttime. Since her plasma cholinesterase (ChE) activity had been persistently zero, she was diagnosed with ChE deficiency. She refused permanent pacemaker implantation, and treatment with positive chronotropic drugs is ongoing. A novel association of ChE deficiency with SSS is theoretically possible rather than coincident, considering that ChE plays a key role in cholinergic influences on the sinus node leading to sinus bradyarrhythmia and on the atria, causing vagally mediated AF.",
author = "Shioto Yasuda and Mitsuhiro Fukata and Taku Yokoyama and Takeshi Arita and Keita Odashiro and Toru Maruyama and Yoichiro Hiramoto and Koichi Akashi",
year = "2019",
month = "1",
day = "1",
doi = "10.2169/internalmedicine.1229-18",
language = "English",
volume = "58",
pages = "809--812",
journal = "Internal Medicine",
issn = "0918-2918",
publisher = "Japanese Society of Internal Medicine",
number = "6",

}

TY - JOUR

T1 - Sick sinus syndrome observed in a patient with cholinesterase deficiency

AU - Yasuda, Shioto

AU - Fukata, Mitsuhiro

AU - Yokoyama, Taku

AU - Arita, Takeshi

AU - Odashiro, Keita

AU - Maruyama, Toru

AU - Hiramoto, Yoichiro

AU - Akashi, Koichi

PY - 2019/1/1

Y1 - 2019/1/1

N2 - A 58-year-old woman complained of general fatigue and was diagnosed with sick sinus syndrome (SSS) by ambulatory electrocardiogram, which demonstrated sinus arrest at midnight and paroxysmal atrial fibrillation (AF) at nighttime. Since her plasma cholinesterase (ChE) activity had been persistently zero, she was diagnosed with ChE deficiency. She refused permanent pacemaker implantation, and treatment with positive chronotropic drugs is ongoing. A novel association of ChE deficiency with SSS is theoretically possible rather than coincident, considering that ChE plays a key role in cholinergic influences on the sinus node leading to sinus bradyarrhythmia and on the atria, causing vagally mediated AF.

AB - A 58-year-old woman complained of general fatigue and was diagnosed with sick sinus syndrome (SSS) by ambulatory electrocardiogram, which demonstrated sinus arrest at midnight and paroxysmal atrial fibrillation (AF) at nighttime. Since her plasma cholinesterase (ChE) activity had been persistently zero, she was diagnosed with ChE deficiency. She refused permanent pacemaker implantation, and treatment with positive chronotropic drugs is ongoing. A novel association of ChE deficiency with SSS is theoretically possible rather than coincident, considering that ChE plays a key role in cholinergic influences on the sinus node leading to sinus bradyarrhythmia and on the atria, causing vagally mediated AF.

UR - http://www.scopus.com/inward/record.url?scp=85063300797&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85063300797&partnerID=8YFLogxK

U2 - 10.2169/internalmedicine.1229-18

DO - 10.2169/internalmedicine.1229-18

M3 - Article

VL - 58

SP - 809

EP - 812

JO - Internal Medicine

JF - Internal Medicine

SN - 0918-2918

IS - 6

ER -