Signal pathway analysis with differentiation markers in osteoblasts stimulated by synthetic analogue to bone mineral

Ryuhei Nishikawa, Takahisa Anada, Osamu Suzuki

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

OCTACALCIUM PHOSPHATE (Ca8H2(PO4) 6·5H2O; OCP) is considered as a precursor of biological apatite crystals in bone and tooth in vertebrates. Recent studies have suggested that osteoblastic cell differentiation is enhanced in contact with OCP which is converted into HA and is significantly facilitated in an OCP dose-dependent manner. MAPK signaling is known to be activated in the early stage of the differentiation from bone marrow-derived mesenchymal stem cells into osteoblasts. However, the MAPK signaling is unclear in relation to the stimulatory capacity of OCP in the osteoblastic differentiation. In this study, we investigated the MAPK signaling during the differentiation of bone marrow-derived stromal cell line leading to the late differentiation stage using gene expression analysis.

Original languageEnglish
Title of host publication2012 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2012
Pages164-168
Number of pages5
DOIs
Publication statusPublished - Dec 1 2012
Externally publishedYes
Event23rd Annual Symposium on Micro-Nano Mechatronics and Human Science, MHS 2012 - Nagoya, Japan
Duration: Nov 4 2012Nov 7 2012

Publication series

Name2012 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2012

Other

Other23rd Annual Symposium on Micro-Nano Mechatronics and Human Science, MHS 2012
CountryJapan
CityNagoya
Period11/4/1211/7/12

All Science Journal Classification (ASJC) codes

  • Electrical and Electronic Engineering
  • Mechanical Engineering

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    Nishikawa, R., Anada, T., & Suzuki, O. (2012). Signal pathway analysis with differentiation markers in osteoblasts stimulated by synthetic analogue to bone mineral. In 2012 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2012 (pp. 164-168). [6492423] (2012 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2012). https://doi.org/10.1109/MHS.2012.6492423