TY - JOUR
T1 - Signal transduction from bradykinin, angiotensin, adrenergic and muscarinic receptors to effector enzymes, including ADP-ribosyl cyclase
AU - Higashida, H.
AU - Yokoyama, S.
AU - Hoshi, N.
AU - Hashii, M.
AU - Egorova, A.
AU - Zhong, Z. G.
AU - Noda, M.
AU - Shahidullah, M.
AU - Taketo, M.
AU - Knijnik, R.
AU - Kimura, Y.
AU - Takahashi, H.
AU - Chen, X. L.
AU - Shin, Y.
AU - Zhang, J. S.
PY - 2001
Y1 - 2001
N2 - Muscarinic acetylcholine receptors in NG108-15 neuroblastoma x glioma cells, and β-adrenergic or angiotensin II receptors in cortical astrocytes and/or ventricular myocytes, utilize the direct signaling pathway to ADP-ribosyl cyclase within cell membranes to produce cyclic ADP-ribose (cADPR) from β-NAD+. This signal cascade is analogous to the previously established transduction pathways from bradykinin receptors to phospholipase Cβ and β-adrenoceptors to adenylyl cyclase via G proteins. Upon receptor stimulation, the newly-formed cADPR may coordinately function to upregulate the release of Ca2+ from the type II ryanodine receptors as well as to facilitate Ca2+ influx through voltage-dependent Ca2+ channels. cADPR interacts with FK506, an immunosuppressant, at FKBP12.6, FK506-binding-protein, and calcineurin, or ryanodine receptors. cADPR also functions through activating calcineurin released from A-kinase anchoring protein (AKAP79). Thus, some Gq/11-coupled receptors can control cADPR-dependent modulation in Ca2+ signaling.
AB - Muscarinic acetylcholine receptors in NG108-15 neuroblastoma x glioma cells, and β-adrenergic or angiotensin II receptors in cortical astrocytes and/or ventricular myocytes, utilize the direct signaling pathway to ADP-ribosyl cyclase within cell membranes to produce cyclic ADP-ribose (cADPR) from β-NAD+. This signal cascade is analogous to the previously established transduction pathways from bradykinin receptors to phospholipase Cβ and β-adrenoceptors to adenylyl cyclase via G proteins. Upon receptor stimulation, the newly-formed cADPR may coordinately function to upregulate the release of Ca2+ from the type II ryanodine receptors as well as to facilitate Ca2+ influx through voltage-dependent Ca2+ channels. cADPR interacts with FK506, an immunosuppressant, at FKBP12.6, FK506-binding-protein, and calcineurin, or ryanodine receptors. cADPR also functions through activating calcineurin released from A-kinase anchoring protein (AKAP79). Thus, some Gq/11-coupled receptors can control cADPR-dependent modulation in Ca2+ signaling.
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U2 - 10.1515/BC.2001.004
DO - 10.1515/BC.2001.004
M3 - Review article
C2 - 11258666
AN - SCOPUS:17744391055
VL - 382
SP - 23
EP - 30
JO - Biological Chemistry
JF - Biological Chemistry
SN - 1431-6730
IS - 1
ER -