Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus

Helena Mira, Zoraida Andreu, Hoonkyo Suh, D. Chichung Lie, Sebastian Jessberger, Antonella Consiglio, Juana San Emeterio, Rafael Hortigüela, María Ángeles Marqués-Torrejón, Kinichi Nakashima, Dilek Colak, Magdalena Götz, Isabel Fariñas, Fred H. Gage

Research output: Contribution to journalArticle

260 Citations (Scopus)

Abstract

Neural stem cells (NSCs) in the adult hippocampus divide infrequently, and the molecules that modulate their quiescence are largely unknown. Here, we show that bone morphogenetic protein (BMP) signaling is active in hippocampal NSCs, downstream of BMPR-IA. BMPs reversibly diminish proliferation of cultured NSCs while maintaining their undifferentiated state. In vivo, acute blockade of BMP signaling in the hippocampus by intracerebral infusion of Noggin first recruits quiescent NSCs into the cycle and increases neurogenesis; subsequently, it leads to decreased stem cell division and depletion of precursors and newborn neurons. Consistently, selective ablation of Bmpr1a in hippocampal NSCs, or inactivation of BMP canonical signaling in conditional Smad4 knockout mice, transiently enhances proliferation but later leads to a reduced number of precursors, thereby limiting neuronal birth. BMPs are therefore required to balance NSC quiescence/ proliferation and to prevent loss of the stem cell activity that supports continuous neurogenesis in the mature hippocampus.

Original languageEnglish
Pages (from-to)78-89
Number of pages12
JournalCell stem cell
Volume7
Issue number1
DOIs
Publication statusPublished - Jul 2010

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Neural Stem Cells
Hippocampus
Bone Morphogenetic Proteins
Neurogenesis
Stem Cells
Knockout Mice
Cell Division
Cell Cycle
Cell Proliferation
Parturition
Neurons

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Genetics
  • Cell Biology

Cite this

Mira, H., Andreu, Z., Suh, H., Chichung Lie, D., Jessberger, S., Consiglio, A., ... Gage, F. H. (2010). Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus. Cell stem cell, 7(1), 78-89. https://doi.org/10.1016/j.stem.2010.04.016

Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus. / Mira, Helena; Andreu, Zoraida; Suh, Hoonkyo; Chichung Lie, D.; Jessberger, Sebastian; Consiglio, Antonella; Emeterio, Juana San; Hortigüela, Rafael; Marqués-Torrejón, María Ángeles; Nakashima, Kinichi; Colak, Dilek; Götz, Magdalena; Fariñas, Isabel; Gage, Fred H.

In: Cell stem cell, Vol. 7, No. 1, 07.2010, p. 78-89.

Research output: Contribution to journalArticle

Mira, H, Andreu, Z, Suh, H, Chichung Lie, D, Jessberger, S, Consiglio, A, Emeterio, JS, Hortigüela, R, Marqués-Torrejón, MÁ, Nakashima, K, Colak, D, Götz, M, Fariñas, I & Gage, FH 2010, 'Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus', Cell stem cell, vol. 7, no. 1, pp. 78-89. https://doi.org/10.1016/j.stem.2010.04.016
Mira, Helena ; Andreu, Zoraida ; Suh, Hoonkyo ; Chichung Lie, D. ; Jessberger, Sebastian ; Consiglio, Antonella ; Emeterio, Juana San ; Hortigüela, Rafael ; Marqués-Torrejón, María Ángeles ; Nakashima, Kinichi ; Colak, Dilek ; Götz, Magdalena ; Fariñas, Isabel ; Gage, Fred H. / Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus. In: Cell stem cell. 2010 ; Vol. 7, No. 1. pp. 78-89.
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