Signaling while eating: MCL is coupled with Mincle

Shou Yamasaki

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    Recently, C-type lectin receptors (CLRs) have been identified as a newly emerging family of pattern-recognition receptors for pathogen-associated molecular patterns. The ligand and function of many "individual" CLRs have been clarified in the past few years. A new report by Lobato-Pascual et al. in this issue of the European Journal of Immunology [Eur. J. Immunol. 2013. 43: 3167-3174] shows that a rat CLR, named macrophage C-type lectin (also called Clec4d), forms a heterodimer with another CLR, macrophage inducible C-type lectin (also called Clec4e). This finding sheds light on a possible synergistic regulation of different C-type lectin receptors by forming heterodimers: such heterodimers may amplify signaling, expand ligand specificity, or confer multiple functions.

    Original languageEnglish
    Pages (from-to)3156-3158
    Number of pages3
    JournalEuropean Journal of Immunology
    Volume43
    Issue number12
    DOIs
    Publication statusPublished - Jan 1 2013

    Fingerprint

    C-Type Lectins
    Eating
    Macrophages
    Ligands
    Pattern Recognition Receptors
    Allergy and Immunology

    All Science Journal Classification (ASJC) codes

    • Immunology
    • Immunology and Allergy

    Cite this

    Signaling while eating : MCL is coupled with Mincle. / Yamasaki, Shou.

    In: European Journal of Immunology, Vol. 43, No. 12, 01.01.2013, p. 3156-3158.

    Research output: Contribution to journalArticle

    Yamasaki, Shou. / Signaling while eating : MCL is coupled with Mincle. In: European Journal of Immunology. 2013 ; Vol. 43, No. 12. pp. 3156-3158.
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