Signalling through MyD88 drives surface expression of the mycobacterial receptors MCL (Clecsf8, Clec4d) and Mincle (Clec4e) following microbial stimulation

Bernhard Kerscher, Ivy M. Dambuza, Maria Christofi, Delyth M. Reid, Sho Yamasaki, Janet A. Willment, Gordon D. Brown

    Research output: Contribution to journalArticlepeer-review

    17 Citations (Scopus)

    Abstract

    The heterodimeric mycobacterial receptors, macrophage C-type lectin (MCL) and macrophage inducible C-type lectin (Mincle), are upregulated at the cell surface following microbial challenge, but the mechanisms underlying this response are unclear. Here we report that microbial stimulation triggers Mincle expression through the myeloid differentiation primary response gene 88 (MyD88) pathway; a process that does not require MCL. Conversely, we show that MCL is constitutively expressed but retained intracellularly until Mincle is induced, whereupon the receptors form heterodimers which are translocated to the cell surface. Thus this “two-step” model for induction of these key receptors provides new insights into the underlying mechanisms of anti-mycobacterial immunity.

    Original languageEnglish
    Pages (from-to)505-509
    Number of pages5
    JournalMicrobes and Infection
    Volume18
    Issue number7-8
    DOIs
    Publication statusPublished - Jul 1 2016

    All Science Journal Classification (ASJC) codes

    • Microbiology
    • Immunology
    • Infectious Diseases

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