Signals controlling the development and activity of regulatory B-lineage cells

Yoshihiro Baba, Masanori Matsumoto, Tomohiro Kurosaki

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The fundamental concepts surrounding B cells with inhibitory function (regulatory B cells) are now being established. In the context of autoimmune and inflammatory animal models, B cells play an immunomodulatory role via IL-10 production and contribute to limitation of the pathogenesis. Recent studies have notably identified the human counterparts of these cells, which have been suggested to be relevant to the pathophysiology of disease. Clear criteria to identify these cell subsets and the key molecular mechanisms underlying their physiological features are required for understanding the big picture of regulatory B cells. Plasmablasts have recently been identified as a major IL-10-producing regulatory B-cell subset and Ca2+ signaling has furthermore been found to contribute to B-cell IL-10 expression. In this review, the signaling components controlling IL-10-dependent B-cell regulatory function and the development of IL-10-competent/-producing B cells and plasmablasts are discussed.

Original languageEnglish
Pages (from-to)487-493
Number of pages7
JournalInternational Immunology
Volume27
Issue number10
DOIs
Publication statusPublished - Oct 2015
Externally publishedYes

Fingerprint

Regulatory B-Lymphocytes
Interleukin-10
B-Lymphocytes
B-Lymphocyte Subsets
Animal Models

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Signals controlling the development and activity of regulatory B-lineage cells. / Baba, Yoshihiro; Matsumoto, Masanori; Kurosaki, Tomohiro.

In: International Immunology, Vol. 27, No. 10, 10.2015, p. 487-493.

Research output: Contribution to journalArticle

Baba, Yoshihiro ; Matsumoto, Masanori ; Kurosaki, Tomohiro. / Signals controlling the development and activity of regulatory B-lineage cells. In: International Immunology. 2015 ; Vol. 27, No. 10. pp. 487-493.
@article{edb303f179874034af2d1937bddbfb71,
title = "Signals controlling the development and activity of regulatory B-lineage cells",
abstract = "The fundamental concepts surrounding B cells with inhibitory function (regulatory B cells) are now being established. In the context of autoimmune and inflammatory animal models, B cells play an immunomodulatory role via IL-10 production and contribute to limitation of the pathogenesis. Recent studies have notably identified the human counterparts of these cells, which have been suggested to be relevant to the pathophysiology of disease. Clear criteria to identify these cell subsets and the key molecular mechanisms underlying their physiological features are required for understanding the big picture of regulatory B cells. Plasmablasts have recently been identified as a major IL-10-producing regulatory B-cell subset and Ca2+ signaling has furthermore been found to contribute to B-cell IL-10 expression. In this review, the signaling components controlling IL-10-dependent B-cell regulatory function and the development of IL-10-competent/-producing B cells and plasmablasts are discussed.",
author = "Yoshihiro Baba and Masanori Matsumoto and Tomohiro Kurosaki",
year = "2015",
month = "10",
doi = "10.1093/intimm/dxv027",
language = "English",
volume = "27",
pages = "487--493",
journal = "International Immunology",
issn = "0953-8178",
publisher = "Oxford University Press",
number = "10",

}

TY - JOUR

T1 - Signals controlling the development and activity of regulatory B-lineage cells

AU - Baba, Yoshihiro

AU - Matsumoto, Masanori

AU - Kurosaki, Tomohiro

PY - 2015/10

Y1 - 2015/10

N2 - The fundamental concepts surrounding B cells with inhibitory function (regulatory B cells) are now being established. In the context of autoimmune and inflammatory animal models, B cells play an immunomodulatory role via IL-10 production and contribute to limitation of the pathogenesis. Recent studies have notably identified the human counterparts of these cells, which have been suggested to be relevant to the pathophysiology of disease. Clear criteria to identify these cell subsets and the key molecular mechanisms underlying their physiological features are required for understanding the big picture of regulatory B cells. Plasmablasts have recently been identified as a major IL-10-producing regulatory B-cell subset and Ca2+ signaling has furthermore been found to contribute to B-cell IL-10 expression. In this review, the signaling components controlling IL-10-dependent B-cell regulatory function and the development of IL-10-competent/-producing B cells and plasmablasts are discussed.

AB - The fundamental concepts surrounding B cells with inhibitory function (regulatory B cells) are now being established. In the context of autoimmune and inflammatory animal models, B cells play an immunomodulatory role via IL-10 production and contribute to limitation of the pathogenesis. Recent studies have notably identified the human counterparts of these cells, which have been suggested to be relevant to the pathophysiology of disease. Clear criteria to identify these cell subsets and the key molecular mechanisms underlying their physiological features are required for understanding the big picture of regulatory B cells. Plasmablasts have recently been identified as a major IL-10-producing regulatory B-cell subset and Ca2+ signaling has furthermore been found to contribute to B-cell IL-10 expression. In this review, the signaling components controlling IL-10-dependent B-cell regulatory function and the development of IL-10-competent/-producing B cells and plasmablasts are discussed.

UR - http://www.scopus.com/inward/record.url?scp=84945490500&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84945490500&partnerID=8YFLogxK

U2 - 10.1093/intimm/dxv027

DO - 10.1093/intimm/dxv027

M3 - Article

C2 - 25957265

AN - SCOPUS:84945490500

VL - 27

SP - 487

EP - 493

JO - International Immunology

JF - International Immunology

SN - 0953-8178

IS - 10

ER -