Significance of allogenic blood transfusion on decreased survival in patients with esophageal carcinoma

Tadahiro Nozoe, Mitsuhiro Miyazaki, Hiroshi Saeki, Takefumi Ohga, Keizo Sugimachi

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

BACKGROUND. To the authors' knowledge, the significance of allogenic blood transfusion in the prognosis of patients with esophageal carcinoma remains controversial. The objective of the current study was to elucidate the correlation, if any, between intraoperative allogenic blood transfusion and prognosis in patients with esophageal carcinoma. METHODS. Two hundred fifty-nine patients with esophageal carcinoma who had undergone esophagectomy and reconstruction were studied. The clinicopathologic data and survival were compared between the 87 patients (33.6%) who received an intraoperative allogenic blood transfusion and the 172 patients (66.4%) who did not. RESULTS. Multivariate analysis demonstrated that the factors that appeared to independently determine prognosis in patients with esophageal carcinoma were the depth of the tumor (P = 0.0001), lymph node metastasis (P < 0.0001), lymphatic invasion (P = 0.0002), venous invasion (P = 0.0008), and the occurrence of postoperative complications (P = 0.034). Intraoperative allogenic blood transfusion was not found to be an independent prognostic indicator. CONCLUSIONS. In the current study, an advanced stage of disease at the time of surgery, which resulted in the need for blood transfusion and the occurrence of postoperative complications, appeared to worsen the prognosis in patients with esophageal carcinoma.

Original languageEnglish
Pages (from-to)1913-1918
Number of pages6
JournalCancer
Volume92
Issue number7
DOIs
Publication statusPublished - Oct 1 2001

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Blood Transfusion
Carcinoma
Survival
Esophagectomy
Multivariate Analysis
Lymph Nodes
Neoplasm Metastasis
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Significance of allogenic blood transfusion on decreased survival in patients with esophageal carcinoma. / Nozoe, Tadahiro; Miyazaki, Mitsuhiro; Saeki, Hiroshi; Ohga, Takefumi; Sugimachi, Keizo.

In: Cancer, Vol. 92, No. 7, 01.10.2001, p. 1913-1918.

Research output: Contribution to journalArticle

Nozoe, Tadahiro ; Miyazaki, Mitsuhiro ; Saeki, Hiroshi ; Ohga, Takefumi ; Sugimachi, Keizo. / Significance of allogenic blood transfusion on decreased survival in patients with esophageal carcinoma. In: Cancer. 2001 ; Vol. 92, No. 7. pp. 1913-1918.
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AB - BACKGROUND. To the authors' knowledge, the significance of allogenic blood transfusion in the prognosis of patients with esophageal carcinoma remains controversial. The objective of the current study was to elucidate the correlation, if any, between intraoperative allogenic blood transfusion and prognosis in patients with esophageal carcinoma. METHODS. Two hundred fifty-nine patients with esophageal carcinoma who had undergone esophagectomy and reconstruction were studied. The clinicopathologic data and survival were compared between the 87 patients (33.6%) who received an intraoperative allogenic blood transfusion and the 172 patients (66.4%) who did not. RESULTS. Multivariate analysis demonstrated that the factors that appeared to independently determine prognosis in patients with esophageal carcinoma were the depth of the tumor (P = 0.0001), lymph node metastasis (P < 0.0001), lymphatic invasion (P = 0.0002), venous invasion (P = 0.0008), and the occurrence of postoperative complications (P = 0.034). Intraoperative allogenic blood transfusion was not found to be an independent prognostic indicator. CONCLUSIONS. In the current study, an advanced stage of disease at the time of surgery, which resulted in the need for blood transfusion and the occurrence of postoperative complications, appeared to worsen the prognosis in patients with esophageal carcinoma.

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