Significance of hepatic resection for hepatocellular carcinoma with sustained virological response to interferon therapy for chronic hepatitis C

Keishi Sugimachi, Nao Kinjo, Masahiko Ikebe, Naoki Yamashita, Eiji Kajiwara, Koshi Mimori, Hidefumi Higashi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Aim: A sustained virological response (SVR) to interferon (IFN) therapy for chronic hepatitis C decreases but does not eliminate the risk of hepatocellular carcinoma (HCC). The significance of hepatectomy for HCC in patients with SVR has not been clarified. The short- and long-term outcomes of hepatectomy for HCC in patients with SVR were studied. Methods: From 2006-2011, 69 patients with chronic hepatitis C underwent hepatic resection for primary HCC in our hospital. Of these, 12 patients (17.4%) had SVR to IFN therapy at the time of hepatectomy. The clinicopathological factors and long-term outcomes of these patients were retrospectively reviewed and were compared with those of patients without SVR. Results: The mean time from achievement of SVR to diagnosis of HCC was 62 months (range, 7-174). The histological inflammation of liver parenchyma had improved after IFN therapy in SVR cases. The preoperative serum alanine transaminase, albumin and prothrombin time were significantly preserved in patients with SVR. Intraoperative blood loss and blood transfusion rate were lower, and recurrence-free survival rate was significantly higher, in patients with SVR. Conclusion: In patients undergoing hepatectomy for HCC, those with SVR had better perioperative safety and a more favorable long-term prognosis than those without SVR.

Original languageEnglish
Pages (from-to)605-609
Number of pages5
JournalHepatology Research
Volume43
Issue number6
DOIs
Publication statusPublished - Jun 1 2013

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Chronic Hepatitis C
Interferons
Hepatocellular Carcinoma
Liver
Hepatectomy
Therapeutics
Prothrombin Time
Alanine Transaminase
Blood Transfusion
Albumins
Survival Rate
Inflammation
Safety
Recurrence
Serum

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Infectious Diseases

Cite this

Significance of hepatic resection for hepatocellular carcinoma with sustained virological response to interferon therapy for chronic hepatitis C. / Sugimachi, Keishi; Kinjo, Nao; Ikebe, Masahiko; Yamashita, Naoki; Kajiwara, Eiji; Mimori, Koshi; Higashi, Hidefumi.

In: Hepatology Research, Vol. 43, No. 6, 01.06.2013, p. 605-609.

Research output: Contribution to journalArticle

Sugimachi, Keishi ; Kinjo, Nao ; Ikebe, Masahiko ; Yamashita, Naoki ; Kajiwara, Eiji ; Mimori, Koshi ; Higashi, Hidefumi. / Significance of hepatic resection for hepatocellular carcinoma with sustained virological response to interferon therapy for chronic hepatitis C. In: Hepatology Research. 2013 ; Vol. 43, No. 6. pp. 605-609.
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