Significance of immunohistochemical expression of cyclooxygenase-2 in squamous cell carcinoma of the esophagus

Tadahiro Nozoe, Takahiro Ezaki, Akira Kabashima, Hideo Baba, Yoshihiko Maehara

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Background: The focus of studies on cyclooxygenase-2 (COX-2) have been on its ability to mediate the biological behavior of human tumors including tumorigenesis, tumor progression, apoptosis, and differentiation. The aim of the current study was to elucidate a further finding on the clinicopathologic significance of immunohistochemical expression of COX-2 in esophageal squamous cell carcinoma (ESCC). Methods: The immunohistochemical expression of COX-2 was examined for 76 specimens of ESCC and the correlation of COX-2 expression with clinicopathologic features was examined. Results: Twenty-eight ESCCs (36.8%) had a strong expression of COX-2. The proportion of poorly differentiated SCCs among tumors with a strong expression of COX-2 (42.8%, 12 of 28) was significantly higher than that among tumors with a weak expression of COX-2 (16.7%, 8 of 48; P =. 037). The depth of the tumors (P =. 003) and the stage of the tumors (P =. 015) were advanced significantly more progressively in ESCCs with a strong COX-2 expression. Univariate analysis showed that the prognosis of patients with ESCCs with a strong COX-2 expression was significantly poorer than that of patients with ESCCs with a weak COX-2 expression (P =. 017). Multivariate analysis showed that only such tumor-related factors as lymphatic invasion (P =. 004), venous invasion (P =. 003), and stage of the tumors (P =. 021) were found to be associated independently with worse prognosis of the patients with ESCC. Conclusions: Strong expression of COX-2 is correlated with tumor progression and poor differentiation in ESCC.

Original languageEnglish
Pages (from-to)110-115
Number of pages6
JournalAmerican Journal of Surgery
Volume189
Issue number1
DOIs
Publication statusPublished - Jan 2005

Fingerprint

Cyclooxygenase 2
Esophagus
Squamous Cell Carcinoma
Neoplasms
Carcinogenesis
Multivariate Analysis
Apoptosis
Esophageal Squamous Cell Carcinoma

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Significance of immunohistochemical expression of cyclooxygenase-2 in squamous cell carcinoma of the esophagus. / Nozoe, Tadahiro; Ezaki, Takahiro; Kabashima, Akira; Baba, Hideo; Maehara, Yoshihiko.

In: American Journal of Surgery, Vol. 189, No. 1, 01.2005, p. 110-115.

Research output: Contribution to journalArticle

Nozoe, Tadahiro ; Ezaki, Takahiro ; Kabashima, Akira ; Baba, Hideo ; Maehara, Yoshihiko. / Significance of immunohistochemical expression of cyclooxygenase-2 in squamous cell carcinoma of the esophagus. In: American Journal of Surgery. 2005 ; Vol. 189, No. 1. pp. 110-115.
@article{679bbc65a36f4802ad3791c00de08077,
title = "Significance of immunohistochemical expression of cyclooxygenase-2 in squamous cell carcinoma of the esophagus",
abstract = "Background: The focus of studies on cyclooxygenase-2 (COX-2) have been on its ability to mediate the biological behavior of human tumors including tumorigenesis, tumor progression, apoptosis, and differentiation. The aim of the current study was to elucidate a further finding on the clinicopathologic significance of immunohistochemical expression of COX-2 in esophageal squamous cell carcinoma (ESCC). Methods: The immunohistochemical expression of COX-2 was examined for 76 specimens of ESCC and the correlation of COX-2 expression with clinicopathologic features was examined. Results: Twenty-eight ESCCs (36.8{\%}) had a strong expression of COX-2. The proportion of poorly differentiated SCCs among tumors with a strong expression of COX-2 (42.8{\%}, 12 of 28) was significantly higher than that among tumors with a weak expression of COX-2 (16.7{\%}, 8 of 48; P =. 037). The depth of the tumors (P =. 003) and the stage of the tumors (P =. 015) were advanced significantly more progressively in ESCCs with a strong COX-2 expression. Univariate analysis showed that the prognosis of patients with ESCCs with a strong COX-2 expression was significantly poorer than that of patients with ESCCs with a weak COX-2 expression (P =. 017). Multivariate analysis showed that only such tumor-related factors as lymphatic invasion (P =. 004), venous invasion (P =. 003), and stage of the tumors (P =. 021) were found to be associated independently with worse prognosis of the patients with ESCC. Conclusions: Strong expression of COX-2 is correlated with tumor progression and poor differentiation in ESCC.",
author = "Tadahiro Nozoe and Takahiro Ezaki and Akira Kabashima and Hideo Baba and Yoshihiko Maehara",
year = "2005",
month = "1",
doi = "10.1016/j.amjsurg.2004.03.019",
language = "English",
volume = "189",
pages = "110--115",
journal = "American Journal of Surgery",
issn = "0002-9610",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Significance of immunohistochemical expression of cyclooxygenase-2 in squamous cell carcinoma of the esophagus

AU - Nozoe, Tadahiro

AU - Ezaki, Takahiro

AU - Kabashima, Akira

AU - Baba, Hideo

AU - Maehara, Yoshihiko

PY - 2005/1

Y1 - 2005/1

N2 - Background: The focus of studies on cyclooxygenase-2 (COX-2) have been on its ability to mediate the biological behavior of human tumors including tumorigenesis, tumor progression, apoptosis, and differentiation. The aim of the current study was to elucidate a further finding on the clinicopathologic significance of immunohistochemical expression of COX-2 in esophageal squamous cell carcinoma (ESCC). Methods: The immunohistochemical expression of COX-2 was examined for 76 specimens of ESCC and the correlation of COX-2 expression with clinicopathologic features was examined. Results: Twenty-eight ESCCs (36.8%) had a strong expression of COX-2. The proportion of poorly differentiated SCCs among tumors with a strong expression of COX-2 (42.8%, 12 of 28) was significantly higher than that among tumors with a weak expression of COX-2 (16.7%, 8 of 48; P =. 037). The depth of the tumors (P =. 003) and the stage of the tumors (P =. 015) were advanced significantly more progressively in ESCCs with a strong COX-2 expression. Univariate analysis showed that the prognosis of patients with ESCCs with a strong COX-2 expression was significantly poorer than that of patients with ESCCs with a weak COX-2 expression (P =. 017). Multivariate analysis showed that only such tumor-related factors as lymphatic invasion (P =. 004), venous invasion (P =. 003), and stage of the tumors (P =. 021) were found to be associated independently with worse prognosis of the patients with ESCC. Conclusions: Strong expression of COX-2 is correlated with tumor progression and poor differentiation in ESCC.

AB - Background: The focus of studies on cyclooxygenase-2 (COX-2) have been on its ability to mediate the biological behavior of human tumors including tumorigenesis, tumor progression, apoptosis, and differentiation. The aim of the current study was to elucidate a further finding on the clinicopathologic significance of immunohistochemical expression of COX-2 in esophageal squamous cell carcinoma (ESCC). Methods: The immunohistochemical expression of COX-2 was examined for 76 specimens of ESCC and the correlation of COX-2 expression with clinicopathologic features was examined. Results: Twenty-eight ESCCs (36.8%) had a strong expression of COX-2. The proportion of poorly differentiated SCCs among tumors with a strong expression of COX-2 (42.8%, 12 of 28) was significantly higher than that among tumors with a weak expression of COX-2 (16.7%, 8 of 48; P =. 037). The depth of the tumors (P =. 003) and the stage of the tumors (P =. 015) were advanced significantly more progressively in ESCCs with a strong COX-2 expression. Univariate analysis showed that the prognosis of patients with ESCCs with a strong COX-2 expression was significantly poorer than that of patients with ESCCs with a weak COX-2 expression (P =. 017). Multivariate analysis showed that only such tumor-related factors as lymphatic invasion (P =. 004), venous invasion (P =. 003), and stage of the tumors (P =. 021) were found to be associated independently with worse prognosis of the patients with ESCC. Conclusions: Strong expression of COX-2 is correlated with tumor progression and poor differentiation in ESCC.

UR - http://www.scopus.com/inward/record.url?scp=13444259438&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=13444259438&partnerID=8YFLogxK

U2 - 10.1016/j.amjsurg.2004.03.019

DO - 10.1016/j.amjsurg.2004.03.019

M3 - Article

C2 - 15701502

AN - SCOPUS:13444259438

VL - 189

SP - 110

EP - 115

JO - American Journal of Surgery

JF - American Journal of Surgery

SN - 0002-9610

IS - 1

ER -