Significance of immunohistochemical over-expression of CD44v6 as an indicator of malignant potential in esophageal squamous cell carcinoma

T. Nozoe, S. Kohnoe, T. Ezaki, A. Kabashima, Y. Maehara

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Purpose: The aim of the current study was to find out a clinicopathologic significance of CD44v6 over-expression in esophageal squamous cell carcinoma (ESCC), which has not been elucidated fully. Methods: Immunohistochemical expression of CD44v6 was examined for 81 ESCCs. Correlation of CD44 over-expression with the clinicopathologic features were investigated. Results: Thirty-eight ESCCs (46.9%) had over-expression of CD44v6. The proportions of the incidence of lymph node metastasis (P = 0.039), lymphatic permeation (P = 0.003), and blood vessel invasion (P = 0.037) in ESCCs with over-expression of CD44v6 were significantly higher than those in ESCCs without over-expression of CD44v6. The stage of the tumor in ESCCs with over-expression of CD44v6 was significantly more advanced (P = 0.045). Survival rates of patients with ESCC with over-expression of CD44v6 were significantly worse (P = 0.0005). Moreover, CD44v6 over-expression (P = 0.048) as well as blood vessel invasion (P = 0.014) and stage of the tumor (P = 0.010) were factors independently associated withthe unfavorable prognosis of the patients with ESCC. Conclusions: Over-expression of CD44v6 can be an indicator of the malignant potential of ESCC.

Original languageEnglish
Pages (from-to)334-338
Number of pages5
JournalJournal of Cancer Research and Clinical Oncology
Volume130
Issue number6
DOIs
Publication statusPublished - Jun 1 2004

Fingerprint

Blood Vessels
Neoplasms
Survival Rate
Lymph Nodes
Neoplasm Metastasis
Esophageal Squamous Cell Carcinoma
Incidence

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Significance of immunohistochemical over-expression of CD44v6 as an indicator of malignant potential in esophageal squamous cell carcinoma. / Nozoe, T.; Kohnoe, S.; Ezaki, T.; Kabashima, A.; Maehara, Y.

In: Journal of Cancer Research and Clinical Oncology, Vol. 130, No. 6, 01.06.2004, p. 334-338.

Research output: Contribution to journalArticle

@article{7a9b18ff4b064a3e9135edec37a53501,
title = "Significance of immunohistochemical over-expression of CD44v6 as an indicator of malignant potential in esophageal squamous cell carcinoma",
abstract = "Purpose: The aim of the current study was to find out a clinicopathologic significance of CD44v6 over-expression in esophageal squamous cell carcinoma (ESCC), which has not been elucidated fully. Methods: Immunohistochemical expression of CD44v6 was examined for 81 ESCCs. Correlation of CD44 over-expression with the clinicopathologic features were investigated. Results: Thirty-eight ESCCs (46.9{\%}) had over-expression of CD44v6. The proportions of the incidence of lymph node metastasis (P = 0.039), lymphatic permeation (P = 0.003), and blood vessel invasion (P = 0.037) in ESCCs with over-expression of CD44v6 were significantly higher than those in ESCCs without over-expression of CD44v6. The stage of the tumor in ESCCs with over-expression of CD44v6 was significantly more advanced (P = 0.045). Survival rates of patients with ESCC with over-expression of CD44v6 were significantly worse (P = 0.0005). Moreover, CD44v6 over-expression (P = 0.048) as well as blood vessel invasion (P = 0.014) and stage of the tumor (P = 0.010) were factors independently associated withthe unfavorable prognosis of the patients with ESCC. Conclusions: Over-expression of CD44v6 can be an indicator of the malignant potential of ESCC.",
author = "T. Nozoe and S. Kohnoe and T. Ezaki and A. Kabashima and Y. Maehara",
year = "2004",
month = "6",
day = "1",
doi = "10.1007/s00432-004-0542-2",
language = "English",
volume = "130",
pages = "334--338",
journal = "Journal of Cancer Research and Clinical Oncology",
issn = "0171-5216",
publisher = "Springer Verlag",
number = "6",

}

TY - JOUR

T1 - Significance of immunohistochemical over-expression of CD44v6 as an indicator of malignant potential in esophageal squamous cell carcinoma

AU - Nozoe, T.

AU - Kohnoe, S.

AU - Ezaki, T.

AU - Kabashima, A.

AU - Maehara, Y.

PY - 2004/6/1

Y1 - 2004/6/1

N2 - Purpose: The aim of the current study was to find out a clinicopathologic significance of CD44v6 over-expression in esophageal squamous cell carcinoma (ESCC), which has not been elucidated fully. Methods: Immunohistochemical expression of CD44v6 was examined for 81 ESCCs. Correlation of CD44 over-expression with the clinicopathologic features were investigated. Results: Thirty-eight ESCCs (46.9%) had over-expression of CD44v6. The proportions of the incidence of lymph node metastasis (P = 0.039), lymphatic permeation (P = 0.003), and blood vessel invasion (P = 0.037) in ESCCs with over-expression of CD44v6 were significantly higher than those in ESCCs without over-expression of CD44v6. The stage of the tumor in ESCCs with over-expression of CD44v6 was significantly more advanced (P = 0.045). Survival rates of patients with ESCC with over-expression of CD44v6 were significantly worse (P = 0.0005). Moreover, CD44v6 over-expression (P = 0.048) as well as blood vessel invasion (P = 0.014) and stage of the tumor (P = 0.010) were factors independently associated withthe unfavorable prognosis of the patients with ESCC. Conclusions: Over-expression of CD44v6 can be an indicator of the malignant potential of ESCC.

AB - Purpose: The aim of the current study was to find out a clinicopathologic significance of CD44v6 over-expression in esophageal squamous cell carcinoma (ESCC), which has not been elucidated fully. Methods: Immunohistochemical expression of CD44v6 was examined for 81 ESCCs. Correlation of CD44 over-expression with the clinicopathologic features were investigated. Results: Thirty-eight ESCCs (46.9%) had over-expression of CD44v6. The proportions of the incidence of lymph node metastasis (P = 0.039), lymphatic permeation (P = 0.003), and blood vessel invasion (P = 0.037) in ESCCs with over-expression of CD44v6 were significantly higher than those in ESCCs without over-expression of CD44v6. The stage of the tumor in ESCCs with over-expression of CD44v6 was significantly more advanced (P = 0.045). Survival rates of patients with ESCC with over-expression of CD44v6 were significantly worse (P = 0.0005). Moreover, CD44v6 over-expression (P = 0.048) as well as blood vessel invasion (P = 0.014) and stage of the tumor (P = 0.010) were factors independently associated withthe unfavorable prognosis of the patients with ESCC. Conclusions: Over-expression of CD44v6 can be an indicator of the malignant potential of ESCC.

UR - http://www.scopus.com/inward/record.url?scp=3042807071&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3042807071&partnerID=8YFLogxK

U2 - 10.1007/s00432-004-0542-2

DO - 10.1007/s00432-004-0542-2

M3 - Article

C2 - 14872339

AN - SCOPUS:3042807071

VL - 130

SP - 334

EP - 338

JO - Journal of Cancer Research and Clinical Oncology

JF - Journal of Cancer Research and Clinical Oncology

SN - 0171-5216

IS - 6

ER -