Significance of INHBA expression in human colorectal cancer

Miho Okano, Hirofumi Yamamoto, Hisataka Ohkuma, Yoshihiro Kano, Hirotoshi Kim, Shimpei Nishikawa, Masamitsu Konno, Koichi Kawamoto, Naotsugu Haraguchi, Ichiro Takemasa, Tsunekazu Mizushima, Masataka Ikeda, Takehiko Yokobori, Koshi Mimori, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori, Hideshi Ishii

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Inhibin β A (INHBA) is a member of the transforming growth factor β (TGF-β) superfamily. INHBA expression is associated with several types of human cancers; however, its significance in colorectal cancer (CRC) is not fully understood. INHBA expression was studied in 126 primary CRC samples and 4 CRC cell lines. Cell growth was assessed after inhibition of INHBA e xpression o r a fter e xogenous overexpression of INHBA in CRC tissues. INHBA expression was significantly higher in CRC tissues when compared to that in the corresponding normal tissues (P<0.001). Patients in the high expression group showed a poorer overall survival rate when compared to those in the low expression group (P<0.001); the present study did not evaluate for an independent prognostic factor but showed the significance of lymph node metastasis as an independent prognostic factor. The present study suggests that INHBA is useful as a predictive marker for prognosis in CRC patients.

Original languageEnglish
Pages (from-to)2903-2908
Number of pages6
JournalOncology reports
Volume30
Issue number6
DOIs
Publication statusPublished - Dec 1 2013

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Colorectal Neoplasms
Transforming Growth Factors
inhibin A
Survival Rate
Lymph Nodes
Neoplasm Metastasis
Cell Line
Growth
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Okano, M., Yamamoto, H., Ohkuma, H., Kano, Y., Kim, H., Nishikawa, S., ... Ishii, H. (2013). Significance of INHBA expression in human colorectal cancer. Oncology reports, 30(6), 2903-2908. https://doi.org/10.3892/or.2013.2761

Significance of INHBA expression in human colorectal cancer. / Okano, Miho; Yamamoto, Hirofumi; Ohkuma, Hisataka; Kano, Yoshihiro; Kim, Hirotoshi; Nishikawa, Shimpei; Konno, Masamitsu; Kawamoto, Koichi; Haraguchi, Naotsugu; Takemasa, Ichiro; Mizushima, Tsunekazu; Ikeda, Masataka; Yokobori, Takehiko; Mimori, Koshi; Sekimoto, Mitsugu; Doki, Yuichiro; Mori, Masaki; Ishii, Hideshi.

In: Oncology reports, Vol. 30, No. 6, 01.12.2013, p. 2903-2908.

Research output: Contribution to journalArticle

Okano, M, Yamamoto, H, Ohkuma, H, Kano, Y, Kim, H, Nishikawa, S, Konno, M, Kawamoto, K, Haraguchi, N, Takemasa, I, Mizushima, T, Ikeda, M, Yokobori, T, Mimori, K, Sekimoto, M, Doki, Y, Mori, M & Ishii, H 2013, 'Significance of INHBA expression in human colorectal cancer', Oncology reports, vol. 30, no. 6, pp. 2903-2908. https://doi.org/10.3892/or.2013.2761
Okano M, Yamamoto H, Ohkuma H, Kano Y, Kim H, Nishikawa S et al. Significance of INHBA expression in human colorectal cancer. Oncology reports. 2013 Dec 1;30(6):2903-2908. https://doi.org/10.3892/or.2013.2761
Okano, Miho ; Yamamoto, Hirofumi ; Ohkuma, Hisataka ; Kano, Yoshihiro ; Kim, Hirotoshi ; Nishikawa, Shimpei ; Konno, Masamitsu ; Kawamoto, Koichi ; Haraguchi, Naotsugu ; Takemasa, Ichiro ; Mizushima, Tsunekazu ; Ikeda, Masataka ; Yokobori, Takehiko ; Mimori, Koshi ; Sekimoto, Mitsugu ; Doki, Yuichiro ; Mori, Masaki ; Ishii, Hideshi. / Significance of INHBA expression in human colorectal cancer. In: Oncology reports. 2013 ; Vol. 30, No. 6. pp. 2903-2908.
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