Abstract
Background: The significance of the Glasgow prognostic score (GPS), an inflammation-based prognostic score, as an indicator of aggressiveness in gastric carcinoma has not been investigated fully. Methods: Two hundred thirty-two patients with gastric carcinoma were enrolled. Patients who had both an elevated C-reactive protein (>1.0 mg/dL) and hypoalbuminemia (<3.5 g/dL) were allocated a traditional GPS (TGPS) of 2. Patients who had one of these abnormal values were allocated a TGPS of 1, and patients who had neither were allocated a TGPS of 0. Results: There existed a significant difference between the survival of adjacent groups of patients when examined using the TGPS (P = .05 for TGPS 0 vs 1 and P = .006 for TGPS 1 vs 2). Multivariate analysis based on TGPS demonstrated that TGPS (P = .020) and tumor stage (P = .0007) proved to be independent prognostic indicators for worse prognosis. Conclusions: The preoperative measurement of an inflammation-based prognostic score can demonstrate a strict stratification for the prognosis of patients with gastric carcinoma.
| Original language | English |
|---|---|
| Pages (from-to) | 186-191 |
| Number of pages | 6 |
| Journal | American Journal of Surgery |
| Volume | 201 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 1 2011 |
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All Science Journal Classification (ASJC) codes
- Surgery
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Significance of modified Glasgow prognostic score as a useful indicator for prognosis of patients with gastric carcinoma. / Nozoe, Tadahiro; Iguchi, Tomohiro; Egashira, Akinori; Adachi, Eisuke; Matsukuma, Akito; Ezaki, Takahiro.
In: American Journal of Surgery, Vol. 201, No. 2, 01.02.2011, p. 186-191.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Significance of modified Glasgow prognostic score as a useful indicator for prognosis of patients with gastric carcinoma
AU - Nozoe, Tadahiro
AU - Iguchi, Tomohiro
AU - Egashira, Akinori
AU - Adachi, Eisuke
AU - Matsukuma, Akito
AU - Ezaki, Takahiro
PY - 2011/2/1
Y1 - 2011/2/1
N2 - Background: The significance of the Glasgow prognostic score (GPS), an inflammation-based prognostic score, as an indicator of aggressiveness in gastric carcinoma has not been investigated fully. Methods: Two hundred thirty-two patients with gastric carcinoma were enrolled. Patients who had both an elevated C-reactive protein (>1.0 mg/dL) and hypoalbuminemia (<3.5 g/dL) were allocated a traditional GPS (TGPS) of 2. Patients who had one of these abnormal values were allocated a TGPS of 1, and patients who had neither were allocated a TGPS of 0. Results: There existed a significant difference between the survival of adjacent groups of patients when examined using the TGPS (P = .05 for TGPS 0 vs 1 and P = .006 for TGPS 1 vs 2). Multivariate analysis based on TGPS demonstrated that TGPS (P = .020) and tumor stage (P = .0007) proved to be independent prognostic indicators for worse prognosis. Conclusions: The preoperative measurement of an inflammation-based prognostic score can demonstrate a strict stratification for the prognosis of patients with gastric carcinoma.
AB - Background: The significance of the Glasgow prognostic score (GPS), an inflammation-based prognostic score, as an indicator of aggressiveness in gastric carcinoma has not been investigated fully. Methods: Two hundred thirty-two patients with gastric carcinoma were enrolled. Patients who had both an elevated C-reactive protein (>1.0 mg/dL) and hypoalbuminemia (<3.5 g/dL) were allocated a traditional GPS (TGPS) of 2. Patients who had one of these abnormal values were allocated a TGPS of 1, and patients who had neither were allocated a TGPS of 0. Results: There existed a significant difference between the survival of adjacent groups of patients when examined using the TGPS (P = .05 for TGPS 0 vs 1 and P = .006 for TGPS 1 vs 2). Multivariate analysis based on TGPS demonstrated that TGPS (P = .020) and tumor stage (P = .0007) proved to be independent prognostic indicators for worse prognosis. Conclusions: The preoperative measurement of an inflammation-based prognostic score can demonstrate a strict stratification for the prognosis of patients with gastric carcinoma.
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UR - http://www.scopus.com/inward/citedby.url?scp=79151483560&partnerID=8YFLogxK
U2 - 10.1016/j.amjsurg.2010.01.030
DO - 10.1016/j.amjsurg.2010.01.030
M3 - Article
VL - 201
SP - 186
EP - 191
JO - American Journal of Surgery
JF - American Journal of Surgery
SN - 0002-9610
IS - 2
ER -