Significance of pancreatic exocrine function in the perioperative management of pancreatoduodenectomy

Ohtsuka Takao, Kenji Kitahara, Satoru Matsuyama, Tomonori Shimonishi, Yuji Nakafusa, Kohji Miyazaki

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background/Aims: The significance of pancreatic exocrine function in the perioperative management of pancreatoduodenectomy (PD) has not been well understood. The aim of this study was to clarify this issue. Methodology: Clinical records of 60 Japanese patients who underwent PD were reviewed retrospectively. Patients were divided into two groups, normal (n=33) and low (n=27) pancreatic exocrine function, according to the preoperative value of N-benzoyl-L-tyrosyl-p-aminobenzoic acid excretion test (normal value >70%). We compared the perioperative events and nutritional status between the two groups. Results: The preoperative and operative characteristics between the two groups were not significantly different. Postoperative pancreatic juice output from the remnant pancreas during the initial 7 days after PD was greater (1145±618 vs. 741±612mL, P=0.02), and the prevalence of pancreatic anastomotic leakage was higher (10/23, 30% vs. 1/27, 4%, P=0.008) in the group with normal pancreatic exocrine function than that in the insufficient group. Perioperative body mass index and serum albumin concentration, which reflect the nutritional status of patients, were significantly lower in the group with low pancreatic exocrine function (P=0.007 and 0.04, respectively). Conclusions: Surgeons should pay more attention to pancreatic anastomotic leakage in patients with normal pancreatic exocrine function after PD. On the other hand, in patients with insufficient exocrine function, perioperative nutritional support should be considered.

Original languageEnglish
Pages (from-to)788-791
Number of pages4
JournalHepato-Gastroenterology
Volume53
Issue number71
Publication statusPublished - Sep 2006
Externally publishedYes

Fingerprint

Pancreaticoduodenectomy
Anastomotic Leak
Nutritional Status
Pancreatic Juice
Nutritional Support
Serum Albumin
Pancreas
Reference Values
Body Mass Index

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Takao, O., Kitahara, K., Matsuyama, S., Shimonishi, T., Nakafusa, Y., & Miyazaki, K. (2006). Significance of pancreatic exocrine function in the perioperative management of pancreatoduodenectomy. Hepato-Gastroenterology, 53(71), 788-791.

Significance of pancreatic exocrine function in the perioperative management of pancreatoduodenectomy. / Takao, Ohtsuka; Kitahara, Kenji; Matsuyama, Satoru; Shimonishi, Tomonori; Nakafusa, Yuji; Miyazaki, Kohji.

In: Hepato-Gastroenterology, Vol. 53, No. 71, 09.2006, p. 788-791.

Research output: Contribution to journalArticle

Takao, O, Kitahara, K, Matsuyama, S, Shimonishi, T, Nakafusa, Y & Miyazaki, K 2006, 'Significance of pancreatic exocrine function in the perioperative management of pancreatoduodenectomy', Hepato-Gastroenterology, vol. 53, no. 71, pp. 788-791.
Takao O, Kitahara K, Matsuyama S, Shimonishi T, Nakafusa Y, Miyazaki K. Significance of pancreatic exocrine function in the perioperative management of pancreatoduodenectomy. Hepato-Gastroenterology. 2006 Sep;53(71):788-791.
Takao, Ohtsuka ; Kitahara, Kenji ; Matsuyama, Satoru ; Shimonishi, Tomonori ; Nakafusa, Yuji ; Miyazaki, Kohji. / Significance of pancreatic exocrine function in the perioperative management of pancreatoduodenectomy. In: Hepato-Gastroenterology. 2006 ; Vol. 53, No. 71. pp. 788-791.
@article{dabf68d75532495484939b4f8dab2a1d,
title = "Significance of pancreatic exocrine function in the perioperative management of pancreatoduodenectomy",
abstract = "Background/Aims: The significance of pancreatic exocrine function in the perioperative management of pancreatoduodenectomy (PD) has not been well understood. The aim of this study was to clarify this issue. Methodology: Clinical records of 60 Japanese patients who underwent PD were reviewed retrospectively. Patients were divided into two groups, normal (n=33) and low (n=27) pancreatic exocrine function, according to the preoperative value of N-benzoyl-L-tyrosyl-p-aminobenzoic acid excretion test (normal value >70{\%}). We compared the perioperative events and nutritional status between the two groups. Results: The preoperative and operative characteristics between the two groups were not significantly different. Postoperative pancreatic juice output from the remnant pancreas during the initial 7 days after PD was greater (1145±618 vs. 741±612mL, P=0.02), and the prevalence of pancreatic anastomotic leakage was higher (10/23, 30{\%} vs. 1/27, 4{\%}, P=0.008) in the group with normal pancreatic exocrine function than that in the insufficient group. Perioperative body mass index and serum albumin concentration, which reflect the nutritional status of patients, were significantly lower in the group with low pancreatic exocrine function (P=0.007 and 0.04, respectively). Conclusions: Surgeons should pay more attention to pancreatic anastomotic leakage in patients with normal pancreatic exocrine function after PD. On the other hand, in patients with insufficient exocrine function, perioperative nutritional support should be considered.",
author = "Ohtsuka Takao and Kenji Kitahara and Satoru Matsuyama and Tomonori Shimonishi and Yuji Nakafusa and Kohji Miyazaki",
year = "2006",
month = "9",
language = "English",
volume = "53",
pages = "788--791",
journal = "Acta hepato-splenologica",
issn = "0172-6390",
publisher = "H.G.E. Update Medical Publishing Ltd.",
number = "71",

}

TY - JOUR

T1 - Significance of pancreatic exocrine function in the perioperative management of pancreatoduodenectomy

AU - Takao, Ohtsuka

AU - Kitahara, Kenji

AU - Matsuyama, Satoru

AU - Shimonishi, Tomonori

AU - Nakafusa, Yuji

AU - Miyazaki, Kohji

PY - 2006/9

Y1 - 2006/9

N2 - Background/Aims: The significance of pancreatic exocrine function in the perioperative management of pancreatoduodenectomy (PD) has not been well understood. The aim of this study was to clarify this issue. Methodology: Clinical records of 60 Japanese patients who underwent PD were reviewed retrospectively. Patients were divided into two groups, normal (n=33) and low (n=27) pancreatic exocrine function, according to the preoperative value of N-benzoyl-L-tyrosyl-p-aminobenzoic acid excretion test (normal value >70%). We compared the perioperative events and nutritional status between the two groups. Results: The preoperative and operative characteristics between the two groups were not significantly different. Postoperative pancreatic juice output from the remnant pancreas during the initial 7 days after PD was greater (1145±618 vs. 741±612mL, P=0.02), and the prevalence of pancreatic anastomotic leakage was higher (10/23, 30% vs. 1/27, 4%, P=0.008) in the group with normal pancreatic exocrine function than that in the insufficient group. Perioperative body mass index and serum albumin concentration, which reflect the nutritional status of patients, were significantly lower in the group with low pancreatic exocrine function (P=0.007 and 0.04, respectively). Conclusions: Surgeons should pay more attention to pancreatic anastomotic leakage in patients with normal pancreatic exocrine function after PD. On the other hand, in patients with insufficient exocrine function, perioperative nutritional support should be considered.

AB - Background/Aims: The significance of pancreatic exocrine function in the perioperative management of pancreatoduodenectomy (PD) has not been well understood. The aim of this study was to clarify this issue. Methodology: Clinical records of 60 Japanese patients who underwent PD were reviewed retrospectively. Patients were divided into two groups, normal (n=33) and low (n=27) pancreatic exocrine function, according to the preoperative value of N-benzoyl-L-tyrosyl-p-aminobenzoic acid excretion test (normal value >70%). We compared the perioperative events and nutritional status between the two groups. Results: The preoperative and operative characteristics between the two groups were not significantly different. Postoperative pancreatic juice output from the remnant pancreas during the initial 7 days after PD was greater (1145±618 vs. 741±612mL, P=0.02), and the prevalence of pancreatic anastomotic leakage was higher (10/23, 30% vs. 1/27, 4%, P=0.008) in the group with normal pancreatic exocrine function than that in the insufficient group. Perioperative body mass index and serum albumin concentration, which reflect the nutritional status of patients, were significantly lower in the group with low pancreatic exocrine function (P=0.007 and 0.04, respectively). Conclusions: Surgeons should pay more attention to pancreatic anastomotic leakage in patients with normal pancreatic exocrine function after PD. On the other hand, in patients with insufficient exocrine function, perioperative nutritional support should be considered.

UR - http://www.scopus.com/inward/record.url?scp=33750576809&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750576809&partnerID=8YFLogxK

M3 - Article

VL - 53

SP - 788

EP - 791

JO - Acta hepato-splenologica

JF - Acta hepato-splenologica

SN - 0172-6390

IS - 71

ER -