Significance of past history of renal failure for the detection of high-risk individuals for cardiovascular and end-stage renal disease: Analysis of data from a nationwide health checkup

Kazunobu Ichikawa, Tsuneo Konta, Ami Ikeda, Shouichi Fujimoto, Kunitoshi Iseki, Toshiki Moriyama, Kunihiro Yamagata, Kazuhiko Tsuruya, Hideaki Yoshida, Koichi Asahi, Issei Kurahashi, Yasuo Ohashi, Tsuyoshi Watanabe

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Clinical information regarding risk factors may be helpful in the detection of various diseases. This cross-sectional study examined the characteristics of subjects with past history of renal failure, and assessed whether this information would be useful for the efficient detection of high-risk individuals for chronic kidney disease (CKD) and cardiovascular disease (CVD) at health checkup. Methods: This study utilized data from a nationwide health checkup, "The Specific Health Check and Guidance in Japan," and data for 250,130 adult subjects were analyzed. Subjects with self-reported history of renal failure and receiving dialysis therapy were defined as having a history of renal failure. Results: Among total participants, there were 1,400 (0.6%) with a history of renal failure. The prevalence of a history of renal failure was higher in subjects with CKD than in those without CKD (1.5 vs. 0.3%, P < 0.001) and increased with progression of the stage of CKD (0.9-43.5%). Subjects with a history of renal failure had a reduced estimated glomerular filtration rate (44.6 ± 20.3 ml/min/1.73 m 2 ) and a higher prevalence of CKD (50.5%) and CVD (31.9%), compared with subjects with hypertension, diabetes or metabolic syndrome. Multivariate logistic regression analysis showed an independent association between a history of CVD and renal failure (odds ratio 3.68, 95% confidence interval 3.26-4.15), after adjustment for confounding factors. Conclusions: A history of renal failure was strongly associated with advanced CKD and CVD. Information regarding history of renal failure could be utilized to efficiently detect high-risk individuals at health checkup.

Original languageEnglish
Pages (from-to)841-847
Number of pages7
JournalClinical and Experimental Nephrology
Volume15
Issue number6
DOIs
Publication statusPublished - Dec 1 2011

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Chronic Kidney Failure
Renal Insufficiency
Chronic Renal Insufficiency
Health
Cardiovascular Diseases
Glomerular Filtration Rate
Dialysis
Japan
Cross-Sectional Studies
Logistic Models
Odds Ratio
Regression Analysis
Confidence Intervals
Hypertension

All Science Journal Classification (ASJC) codes

  • Physiology
  • Nephrology
  • Physiology (medical)

Cite this

Significance of past history of renal failure for the detection of high-risk individuals for cardiovascular and end-stage renal disease : Analysis of data from a nationwide health checkup. / Ichikawa, Kazunobu; Konta, Tsuneo; Ikeda, Ami; Fujimoto, Shouichi; Iseki, Kunitoshi; Moriyama, Toshiki; Yamagata, Kunihiro; Tsuruya, Kazuhiko; Yoshida, Hideaki; Asahi, Koichi; Kurahashi, Issei; Ohashi, Yasuo; Watanabe, Tsuyoshi.

In: Clinical and Experimental Nephrology, Vol. 15, No. 6, 01.12.2011, p. 841-847.

Research output: Contribution to journalArticle

Ichikawa, K, Konta, T, Ikeda, A, Fujimoto, S, Iseki, K, Moriyama, T, Yamagata, K, Tsuruya, K, Yoshida, H, Asahi, K, Kurahashi, I, Ohashi, Y & Watanabe, T 2011, 'Significance of past history of renal failure for the detection of high-risk individuals for cardiovascular and end-stage renal disease: Analysis of data from a nationwide health checkup', Clinical and Experimental Nephrology, vol. 15, no. 6, pp. 841-847. https://doi.org/10.1007/s10157-011-0509-y
Ichikawa, Kazunobu ; Konta, Tsuneo ; Ikeda, Ami ; Fujimoto, Shouichi ; Iseki, Kunitoshi ; Moriyama, Toshiki ; Yamagata, Kunihiro ; Tsuruya, Kazuhiko ; Yoshida, Hideaki ; Asahi, Koichi ; Kurahashi, Issei ; Ohashi, Yasuo ; Watanabe, Tsuyoshi. / Significance of past history of renal failure for the detection of high-risk individuals for cardiovascular and end-stage renal disease : Analysis of data from a nationwide health checkup. In: Clinical and Experimental Nephrology. 2011 ; Vol. 15, No. 6. pp. 841-847.
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T1 - Significance of past history of renal failure for the detection of high-risk individuals for cardiovascular and end-stage renal disease

T2 - Analysis of data from a nationwide health checkup

AU - Ichikawa, Kazunobu

AU - Konta, Tsuneo

AU - Ikeda, Ami

AU - Fujimoto, Shouichi

AU - Iseki, Kunitoshi

AU - Moriyama, Toshiki

AU - Yamagata, Kunihiro

AU - Tsuruya, Kazuhiko

AU - Yoshida, Hideaki

AU - Asahi, Koichi

AU - Kurahashi, Issei

AU - Ohashi, Yasuo

AU - Watanabe, Tsuyoshi

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Background: Clinical information regarding risk factors may be helpful in the detection of various diseases. This cross-sectional study examined the characteristics of subjects with past history of renal failure, and assessed whether this information would be useful for the efficient detection of high-risk individuals for chronic kidney disease (CKD) and cardiovascular disease (CVD) at health checkup. Methods: This study utilized data from a nationwide health checkup, "The Specific Health Check and Guidance in Japan," and data for 250,130 adult subjects were analyzed. Subjects with self-reported history of renal failure and receiving dialysis therapy were defined as having a history of renal failure. Results: Among total participants, there were 1,400 (0.6%) with a history of renal failure. The prevalence of a history of renal failure was higher in subjects with CKD than in those without CKD (1.5 vs. 0.3%, P < 0.001) and increased with progression of the stage of CKD (0.9-43.5%). Subjects with a history of renal failure had a reduced estimated glomerular filtration rate (44.6 ± 20.3 ml/min/1.73 m 2 ) and a higher prevalence of CKD (50.5%) and CVD (31.9%), compared with subjects with hypertension, diabetes or metabolic syndrome. Multivariate logistic regression analysis showed an independent association between a history of CVD and renal failure (odds ratio 3.68, 95% confidence interval 3.26-4.15), after adjustment for confounding factors. Conclusions: A history of renal failure was strongly associated with advanced CKD and CVD. Information regarding history of renal failure could be utilized to efficiently detect high-risk individuals at health checkup.

AB - Background: Clinical information regarding risk factors may be helpful in the detection of various diseases. This cross-sectional study examined the characteristics of subjects with past history of renal failure, and assessed whether this information would be useful for the efficient detection of high-risk individuals for chronic kidney disease (CKD) and cardiovascular disease (CVD) at health checkup. Methods: This study utilized data from a nationwide health checkup, "The Specific Health Check and Guidance in Japan," and data for 250,130 adult subjects were analyzed. Subjects with self-reported history of renal failure and receiving dialysis therapy were defined as having a history of renal failure. Results: Among total participants, there were 1,400 (0.6%) with a history of renal failure. The prevalence of a history of renal failure was higher in subjects with CKD than in those without CKD (1.5 vs. 0.3%, P < 0.001) and increased with progression of the stage of CKD (0.9-43.5%). Subjects with a history of renal failure had a reduced estimated glomerular filtration rate (44.6 ± 20.3 ml/min/1.73 m 2 ) and a higher prevalence of CKD (50.5%) and CVD (31.9%), compared with subjects with hypertension, diabetes or metabolic syndrome. Multivariate logistic regression analysis showed an independent association between a history of CVD and renal failure (odds ratio 3.68, 95% confidence interval 3.26-4.15), after adjustment for confounding factors. Conclusions: A history of renal failure was strongly associated with advanced CKD and CVD. Information regarding history of renal failure could be utilized to efficiently detect high-risk individuals at health checkup.

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