Significance of preoperative elevation of serum C-reactive protein as an indicator of prognosis in esophageal carcinoma

Tadahiro Nozoe, Hiroshi Saeki, Keizo Sugimachi

Research output: Contribution to journalArticle

147 Citations (Scopus)

Abstract

Background: Preoperative elevation of serum C-reactive protein (CRP) has been reported to be a prognostic indicator in gastric carcinoma and colorectal carcinoma. The aim of this study was to establish the significance of preoperative elevation of serum CRP as an indicator of prognosis in patients with esophageal carcinoma. Methods: Two hundred sixty-two patients with esophageal carcinoma who had been treated by esophageal resection and reconstruction of digestive tracts were evaluated, excluding patients with neoplasms in other organs. Preoperative serum CRP was measured, and the relation between the elevation of serum CRP and the clinicopathological factors and prognosis of the patients was investigated. Results: The mean size of the tumors and the proportions of lymph node metastasis and lymphatic invasion were significantly larger in patients with preoperative elevation of serum CRP than in patients without preoperative elevation of serum CRP (5.8 ± 2.5 cm versus 4.8 ± 2.5 cm, P <0.01, 59.5% versus 35.4%, P <0.001, and 35.7% versus 23.6%, P <0.05, respectively). 1-, 3-, and 5-year survival rates in patients with preoperative elevation of serum CRP (60.6%, 18.4%, and 11.5%, respectively) were significantly lower than those in patients without preoperative elevation of serum CRP (88.7%, 70.9%, and 68.4%, respectively; P <0.0001). Multivariate analysis demonstrated that the preoperative elevation of serum CRP was an independent prognostic factor in esophageal carcinoma (P <0.0001). Conclusions: The preoperative serum elevation of CRP can be a marker of the malignant potential of the tumor and an independent prognostic indicator in esophageal carcinoma.

Original languageEnglish
Pages (from-to)197-201
Number of pages5
JournalAmerican Journal of Surgery
Volume182
Issue number2
DOIs
Publication statusPublished - Oct 9 2001

Fingerprint

C-Reactive Protein
Blood Proteins
Carcinoma
Lymphatic Metastasis
Neoplasms
Gastrointestinal Tract
Colorectal Neoplasms
Stomach
Multivariate Analysis
Survival Rate
Lymph Nodes
Serum

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Significance of preoperative elevation of serum C-reactive protein as an indicator of prognosis in esophageal carcinoma. / Nozoe, Tadahiro; Saeki, Hiroshi; Sugimachi, Keizo.

In: American Journal of Surgery, Vol. 182, No. 2, 09.10.2001, p. 197-201.

Research output: Contribution to journalArticle

Nozoe, Tadahiro ; Saeki, Hiroshi ; Sugimachi, Keizo. / Significance of preoperative elevation of serum C-reactive protein as an indicator of prognosis in esophageal carcinoma. In: American Journal of Surgery. 2001 ; Vol. 182, No. 2. pp. 197-201.
@article{f3a32c8bc644431aa36242baa5001128,
title = "Significance of preoperative elevation of serum C-reactive protein as an indicator of prognosis in esophageal carcinoma",
abstract = "Background: Preoperative elevation of serum C-reactive protein (CRP) has been reported to be a prognostic indicator in gastric carcinoma and colorectal carcinoma. The aim of this study was to establish the significance of preoperative elevation of serum CRP as an indicator of prognosis in patients with esophageal carcinoma. Methods: Two hundred sixty-two patients with esophageal carcinoma who had been treated by esophageal resection and reconstruction of digestive tracts were evaluated, excluding patients with neoplasms in other organs. Preoperative serum CRP was measured, and the relation between the elevation of serum CRP and the clinicopathological factors and prognosis of the patients was investigated. Results: The mean size of the tumors and the proportions of lymph node metastasis and lymphatic invasion were significantly larger in patients with preoperative elevation of serum CRP than in patients without preoperative elevation of serum CRP (5.8 ± 2.5 cm versus 4.8 ± 2.5 cm, P <0.01, 59.5{\%} versus 35.4{\%}, P <0.001, and 35.7{\%} versus 23.6{\%}, P <0.05, respectively). 1-, 3-, and 5-year survival rates in patients with preoperative elevation of serum CRP (60.6{\%}, 18.4{\%}, and 11.5{\%}, respectively) were significantly lower than those in patients without preoperative elevation of serum CRP (88.7{\%}, 70.9{\%}, and 68.4{\%}, respectively; P <0.0001). Multivariate analysis demonstrated that the preoperative elevation of serum CRP was an independent prognostic factor in esophageal carcinoma (P <0.0001). Conclusions: The preoperative serum elevation of CRP can be a marker of the malignant potential of the tumor and an independent prognostic indicator in esophageal carcinoma.",
author = "Tadahiro Nozoe and Hiroshi Saeki and Keizo Sugimachi",
year = "2001",
month = "10",
day = "9",
doi = "10.1016/S0002-9610(01)00684-5",
language = "English",
volume = "182",
pages = "197--201",
journal = "American Journal of Surgery",
issn = "0002-9610",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Significance of preoperative elevation of serum C-reactive protein as an indicator of prognosis in esophageal carcinoma

AU - Nozoe, Tadahiro

AU - Saeki, Hiroshi

AU - Sugimachi, Keizo

PY - 2001/10/9

Y1 - 2001/10/9

N2 - Background: Preoperative elevation of serum C-reactive protein (CRP) has been reported to be a prognostic indicator in gastric carcinoma and colorectal carcinoma. The aim of this study was to establish the significance of preoperative elevation of serum CRP as an indicator of prognosis in patients with esophageal carcinoma. Methods: Two hundred sixty-two patients with esophageal carcinoma who had been treated by esophageal resection and reconstruction of digestive tracts were evaluated, excluding patients with neoplasms in other organs. Preoperative serum CRP was measured, and the relation between the elevation of serum CRP and the clinicopathological factors and prognosis of the patients was investigated. Results: The mean size of the tumors and the proportions of lymph node metastasis and lymphatic invasion were significantly larger in patients with preoperative elevation of serum CRP than in patients without preoperative elevation of serum CRP (5.8 ± 2.5 cm versus 4.8 ± 2.5 cm, P <0.01, 59.5% versus 35.4%, P <0.001, and 35.7% versus 23.6%, P <0.05, respectively). 1-, 3-, and 5-year survival rates in patients with preoperative elevation of serum CRP (60.6%, 18.4%, and 11.5%, respectively) were significantly lower than those in patients without preoperative elevation of serum CRP (88.7%, 70.9%, and 68.4%, respectively; P <0.0001). Multivariate analysis demonstrated that the preoperative elevation of serum CRP was an independent prognostic factor in esophageal carcinoma (P <0.0001). Conclusions: The preoperative serum elevation of CRP can be a marker of the malignant potential of the tumor and an independent prognostic indicator in esophageal carcinoma.

AB - Background: Preoperative elevation of serum C-reactive protein (CRP) has been reported to be a prognostic indicator in gastric carcinoma and colorectal carcinoma. The aim of this study was to establish the significance of preoperative elevation of serum CRP as an indicator of prognosis in patients with esophageal carcinoma. Methods: Two hundred sixty-two patients with esophageal carcinoma who had been treated by esophageal resection and reconstruction of digestive tracts were evaluated, excluding patients with neoplasms in other organs. Preoperative serum CRP was measured, and the relation between the elevation of serum CRP and the clinicopathological factors and prognosis of the patients was investigated. Results: The mean size of the tumors and the proportions of lymph node metastasis and lymphatic invasion were significantly larger in patients with preoperative elevation of serum CRP than in patients without preoperative elevation of serum CRP (5.8 ± 2.5 cm versus 4.8 ± 2.5 cm, P <0.01, 59.5% versus 35.4%, P <0.001, and 35.7% versus 23.6%, P <0.05, respectively). 1-, 3-, and 5-year survival rates in patients with preoperative elevation of serum CRP (60.6%, 18.4%, and 11.5%, respectively) were significantly lower than those in patients without preoperative elevation of serum CRP (88.7%, 70.9%, and 68.4%, respectively; P <0.0001). Multivariate analysis demonstrated that the preoperative elevation of serum CRP was an independent prognostic factor in esophageal carcinoma (P <0.0001). Conclusions: The preoperative serum elevation of CRP can be a marker of the malignant potential of the tumor and an independent prognostic indicator in esophageal carcinoma.

UR - http://www.scopus.com/inward/record.url?scp=0034808015&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034808015&partnerID=8YFLogxK

U2 - 10.1016/S0002-9610(01)00684-5

DO - 10.1016/S0002-9610(01)00684-5

M3 - Article

VL - 182

SP - 197

EP - 201

JO - American Journal of Surgery

JF - American Journal of Surgery

SN - 0002-9610

IS - 2

ER -