Significance of PSA/AR expression in extramammary Paget's disease

Neng Xing Lin, Hou Jin Liu, Kazunori Urabe, Masutaka Furue, Ya Ting Tu

Research output: Contribution to journalArticle

Abstract

Objective: To investigate the expression and significance of prostate specific antigen (PSA) and androgen receptor(AR) in extramammary Paget's disease (EMPD). Methods: Thirty tissue specimens of EMPD cases were analyzed by immunohistochemical staining in formalin-fixed, paraffin-embedded tissue sections for PSA and AR. Results: The positive expression of PSA and AR among the 30 specimens of EMPD was 13 and 14 respectively. Moreover, the expression of PSA and AR in specimens from the male cases was higher than that from the female cases (P<0.01). There was significant correlation between PSA and AR expression in EMPD. Conclusions: This study provides evidence that the overexpression of PSA and AR is existed in EMPD of the male cases, indicating that PSA/AR signaling pathway may play a pivotal role in the oncogenesis of EMPD of the male.

Original languageEnglish
Pages (from-to)77-79
Number of pages3
JournalJournal of Clinical Dermatology
Volume36
Issue number2
Publication statusPublished - Feb 2007
Externally publishedYes

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Extramammary Paget's Disease
Antigen Receptors
Androgen Receptors
Prostate-Specific Antigen
Paraffin
Formaldehyde
Carcinogenesis
Staining and Labeling

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Lin, N. X., Liu, H. J., Urabe, K., Furue, M., & Tu, Y. T. (2007). Significance of PSA/AR expression in extramammary Paget's disease. Journal of Clinical Dermatology, 36(2), 77-79.

Significance of PSA/AR expression in extramammary Paget's disease. / Lin, Neng Xing; Liu, Hou Jin; Urabe, Kazunori; Furue, Masutaka; Tu, Ya Ting.

In: Journal of Clinical Dermatology, Vol. 36, No. 2, 02.2007, p. 77-79.

Research output: Contribution to journalArticle

Lin, NX, Liu, HJ, Urabe, K, Furue, M & Tu, YT 2007, 'Significance of PSA/AR expression in extramammary Paget's disease', Journal of Clinical Dermatology, vol. 36, no. 2, pp. 77-79.
Lin, Neng Xing ; Liu, Hou Jin ; Urabe, Kazunori ; Furue, Masutaka ; Tu, Ya Ting. / Significance of PSA/AR expression in extramammary Paget's disease. In: Journal of Clinical Dermatology. 2007 ; Vol. 36, No. 2. pp. 77-79.
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