Significant suppression of rat liver aldolase B by a toxic coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl

Yuji Ishii, Harutoshi Kato, Megumu Hatsumura, Takumi Ishida, Noritaka Ariyoshi, Kazuta Oguri

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A toxic coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl (PenCB), significantly suppresses the expression of liver aldolase B in rats. Hepatic aldolase activity in PenCB-treated rats was significantly reduced to about 50% of that in free- and pair-fed control groups. The reduced aldolase activity following PenCB-treatment was due to the marked suppression of the expression of aldolase B shown by immunoblot analysis after SDS-polyacrylamide gel electrophoresis and two-dimensional gel electrophoresis. The suppression of rat liver aldolase B could be a key biochemical lesion caused by PenCB.

Original languageEnglish
Pages (from-to)193-199
Number of pages7
JournalToxicology
Volume116
Issue number1-3
DOIs
Publication statusPublished - Jan 15 1997

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3,4,5,3',4'-pentachlorobiphenyl
Fructose-Bisphosphate Aldolase
Poisons
Polychlorinated Biphenyls
Liver
Rats
Electrophoresis
Electrophoresis, Gel, Two-Dimensional
Polyacrylamide Gel Electrophoresis
Gels
Control Groups

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

Significant suppression of rat liver aldolase B by a toxic coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl. / Ishii, Yuji; Kato, Harutoshi; Hatsumura, Megumu; Ishida, Takumi; Ariyoshi, Noritaka; Oguri, Kazuta.

In: Toxicology, Vol. 116, No. 1-3, 15.01.1997, p. 193-199.

Research output: Contribution to journalArticle

Ishii, Yuji ; Kato, Harutoshi ; Hatsumura, Megumu ; Ishida, Takumi ; Ariyoshi, Noritaka ; Oguri, Kazuta. / Significant suppression of rat liver aldolase B by a toxic coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl. In: Toxicology. 1997 ; Vol. 116, No. 1-3. pp. 193-199.
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