Abstract
Objective: To conduct a review and meta-analysis of the effect of diabetes mellitus on the incidence of and mortality attributable to cancer at any anatomic site.Methods: We performed a search of MEDLINE and the Cochrane Library for pertinent articles published from the origin of these databases to July 5, 2010, and included them in a qualitative review and meta-analysis of the risk of all-cancer incidence and mortality in patients with diabetes.Results: Among patients with diabetes (n = 257,222) in 12 cohort studies, the cancer incidence was about 7%. The cancer mortality was approximately 3% among patients with diabetes (n = 152,091) in 19 cohort studies. The pooled adjusted risk ratio (RR) of all-cancer incidence was significantly elevated-RR, 1.10 (95% confidence interval [CI], 1.04 to 1.17) overall; RR, 1.14 (CI, 1.06 to 1.23) for men; and RR, 1.18 (CI, 1.08 to 1.28) for women. Diabetes was also associated with an increased RR of mortality across all cancer types-RR, 1.16 (CI, 1.03 to 1.30) overall; RR, 1.10 (CI, 0.98 to 1.23) for men; and RR, 1.24 (CI, 1.11 to 1.40) for women.Conclusion: Cancer prevention and early detection by appropriate screening methods in patients with diabetes should be important components of clinical management and investigation, inasmuch as the exponentially increasing prevalence of diabetes will translate into substantial clinical and public health consequences on a global scale.
| Original language | English |
|---|---|
| Pages (from-to) | 616-628 |
| Number of pages | 13 |
| Journal | Endocrine Practice |
| Volume | 17 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jul 1 2011 |
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All Science Journal Classification (ASJC) codes
- Endocrinology, Diabetes and Metabolism
- Endocrinology
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Significantly increased risk of cancer in patients with diabetes mellitus : A systematic review and meta-analysis. / Noto, Hiroshi; Tsujimoto, Tetsuro; Sasazuki, Takehiko; Noda, Mitsuhiko.
In: Endocrine Practice, Vol. 17, No. 4, 01.07.2011, p. 616-628.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Significantly increased risk of cancer in patients with diabetes mellitus
T2 - A systematic review and meta-analysis
AU - Noto, Hiroshi
AU - Tsujimoto, Tetsuro
AU - Sasazuki, Takehiko
AU - Noda, Mitsuhiko
PY - 2011/7/1
Y1 - 2011/7/1
N2 - Objective: To conduct a review and meta-analysis of the effect of diabetes mellitus on the incidence of and mortality attributable to cancer at any anatomic site.Methods: We performed a search of MEDLINE and the Cochrane Library for pertinent articles published from the origin of these databases to July 5, 2010, and included them in a qualitative review and meta-analysis of the risk of all-cancer incidence and mortality in patients with diabetes.Results: Among patients with diabetes (n = 257,222) in 12 cohort studies, the cancer incidence was about 7%. The cancer mortality was approximately 3% among patients with diabetes (n = 152,091) in 19 cohort studies. The pooled adjusted risk ratio (RR) of all-cancer incidence was significantly elevated-RR, 1.10 (95% confidence interval [CI], 1.04 to 1.17) overall; RR, 1.14 (CI, 1.06 to 1.23) for men; and RR, 1.18 (CI, 1.08 to 1.28) for women. Diabetes was also associated with an increased RR of mortality across all cancer types-RR, 1.16 (CI, 1.03 to 1.30) overall; RR, 1.10 (CI, 0.98 to 1.23) for men; and RR, 1.24 (CI, 1.11 to 1.40) for women.Conclusion: Cancer prevention and early detection by appropriate screening methods in patients with diabetes should be important components of clinical management and investigation, inasmuch as the exponentially increasing prevalence of diabetes will translate into substantial clinical and public health consequences on a global scale.
AB - Objective: To conduct a review and meta-analysis of the effect of diabetes mellitus on the incidence of and mortality attributable to cancer at any anatomic site.Methods: We performed a search of MEDLINE and the Cochrane Library for pertinent articles published from the origin of these databases to July 5, 2010, and included them in a qualitative review and meta-analysis of the risk of all-cancer incidence and mortality in patients with diabetes.Results: Among patients with diabetes (n = 257,222) in 12 cohort studies, the cancer incidence was about 7%. The cancer mortality was approximately 3% among patients with diabetes (n = 152,091) in 19 cohort studies. The pooled adjusted risk ratio (RR) of all-cancer incidence was significantly elevated-RR, 1.10 (95% confidence interval [CI], 1.04 to 1.17) overall; RR, 1.14 (CI, 1.06 to 1.23) for men; and RR, 1.18 (CI, 1.08 to 1.28) for women. Diabetes was also associated with an increased RR of mortality across all cancer types-RR, 1.16 (CI, 1.03 to 1.30) overall; RR, 1.10 (CI, 0.98 to 1.23) for men; and RR, 1.24 (CI, 1.11 to 1.40) for women.Conclusion: Cancer prevention and early detection by appropriate screening methods in patients with diabetes should be important components of clinical management and investigation, inasmuch as the exponentially increasing prevalence of diabetes will translate into substantial clinical and public health consequences on a global scale.
UR - http://www.scopus.com/inward/record.url?scp=84860390016&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860390016&partnerID=8YFLogxK
U2 - 10.4158/EP10357.RA
DO - 10.4158/EP10357.RA
M3 - Review article
C2 - 21454235
AN - SCOPUS:84860390016
VL - 17
SP - 616
EP - 628
JO - Endocrine Practice
JF - Endocrine Practice
SN - 1530-891X
IS - 4
ER -