Similarity of visual selectivity among clonally related neurons in visual cortex

Gen Ohtsuki, Megumi Nishiyama, Takashi Yoshida, Tomonari Murakami, Mark Histed, Carlos Lois, Kenichi Ohki

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Neurons in rodent visual cortex are organized in a salt-and-pepper fashion for orientation selectivity, but it is still unknown how this functional architecture develops. A recent study reported that the progeny of single cortical progenitor cells are preferentially connected in the postnatal cortex. If these neurons acquire similar selectivity through their connections, a salt-and-pepper organization may be generated, because neurons derived from different progenitors are intermingled in rodents. Here we investigated whether clonally related cells have similar preferred orientation by using a transgenic mouse, which labels all the progeny of single cortical progenitor cells. We found that preferred orientations of clonally related cells are similar to each other, suggesting that cell lineage is involved in the development of response selectivity of neurons in the cortex. However, not all clonally related cells share response selectivity, suggesting that cell lineage is not the only determinant of response selectivity.

Original languageEnglish
Pages (from-to)65-72
Number of pages8
JournalNeuron
Volume75
Issue number1
DOIs
Publication statusPublished - Jul 12 2012

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Visual Cortex
Neurons
Cell Lineage
Rodentia
Stem Cells
Salts
Transgenic Mice

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Ohtsuki, G., Nishiyama, M., Yoshida, T., Murakami, T., Histed, M., Lois, C., & Ohki, K. (2012). Similarity of visual selectivity among clonally related neurons in visual cortex. Neuron, 75(1), 65-72. https://doi.org/10.1016/j.neuron.2012.05.023

Similarity of visual selectivity among clonally related neurons in visual cortex. / Ohtsuki, Gen; Nishiyama, Megumi; Yoshida, Takashi; Murakami, Tomonari; Histed, Mark; Lois, Carlos; Ohki, Kenichi.

In: Neuron, Vol. 75, No. 1, 12.07.2012, p. 65-72.

Research output: Contribution to journalArticle

Ohtsuki, G, Nishiyama, M, Yoshida, T, Murakami, T, Histed, M, Lois, C & Ohki, K 2012, 'Similarity of visual selectivity among clonally related neurons in visual cortex', Neuron, vol. 75, no. 1, pp. 65-72. https://doi.org/10.1016/j.neuron.2012.05.023
Ohtsuki G, Nishiyama M, Yoshida T, Murakami T, Histed M, Lois C et al. Similarity of visual selectivity among clonally related neurons in visual cortex. Neuron. 2012 Jul 12;75(1):65-72. https://doi.org/10.1016/j.neuron.2012.05.023
Ohtsuki, Gen ; Nishiyama, Megumi ; Yoshida, Takashi ; Murakami, Tomonari ; Histed, Mark ; Lois, Carlos ; Ohki, Kenichi. / Similarity of visual selectivity among clonally related neurons in visual cortex. In: Neuron. 2012 ; Vol. 75, No. 1. pp. 65-72.
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