Abstract
Neurons in rodent visual cortex are organized in a salt-and-pepper fashion for orientation selectivity, but it is still unknown how this functional architecture develops. A recent study reported that the progeny of single cortical progenitor cells are preferentially connected in the postnatal cortex. If these neurons acquire similar selectivity through their connections, a salt-and-pepper organization may be generated, because neurons derived from different progenitors are intermingled in rodents. Here we investigated whether clonally related cells have similar preferred orientation by using a transgenic mouse, which labels all the progeny of single cortical progenitor cells. We found that preferred orientations of clonally related cells are similar to each other, suggesting that cell lineage is involved in the development of response selectivity of neurons in the cortex. However, not all clonally related cells share response selectivity, suggesting that cell lineage is not the only determinant of response selectivity.
| Original language | English |
|---|---|
| Pages (from-to) | 65-72 |
| Number of pages | 8 |
| Journal | Neuron |
| Volume | 75 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jul 12 2012 |
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All Science Journal Classification (ASJC) codes
- Neuroscience(all)
Cite this
Similarity of visual selectivity among clonally related neurons in visual cortex. / Ohtsuki, Gen; Nishiyama, Megumi; Yoshida, Takashi; Murakami, Tomonari; Histed, Mark; Lois, Carlos; Ohki, Kenichi.
In: Neuron, Vol. 75, No. 1, 12.07.2012, p. 65-72.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Similarity of visual selectivity among clonally related neurons in visual cortex
AU - Ohtsuki, Gen
AU - Nishiyama, Megumi
AU - Yoshida, Takashi
AU - Murakami, Tomonari
AU - Histed, Mark
AU - Lois, Carlos
AU - Ohki, Kenichi
PY - 2012/7/12
Y1 - 2012/7/12
N2 - Neurons in rodent visual cortex are organized in a salt-and-pepper fashion for orientation selectivity, but it is still unknown how this functional architecture develops. A recent study reported that the progeny of single cortical progenitor cells are preferentially connected in the postnatal cortex. If these neurons acquire similar selectivity through their connections, a salt-and-pepper organization may be generated, because neurons derived from different progenitors are intermingled in rodents. Here we investigated whether clonally related cells have similar preferred orientation by using a transgenic mouse, which labels all the progeny of single cortical progenitor cells. We found that preferred orientations of clonally related cells are similar to each other, suggesting that cell lineage is involved in the development of response selectivity of neurons in the cortex. However, not all clonally related cells share response selectivity, suggesting that cell lineage is not the only determinant of response selectivity.
AB - Neurons in rodent visual cortex are organized in a salt-and-pepper fashion for orientation selectivity, but it is still unknown how this functional architecture develops. A recent study reported that the progeny of single cortical progenitor cells are preferentially connected in the postnatal cortex. If these neurons acquire similar selectivity through their connections, a salt-and-pepper organization may be generated, because neurons derived from different progenitors are intermingled in rodents. Here we investigated whether clonally related cells have similar preferred orientation by using a transgenic mouse, which labels all the progeny of single cortical progenitor cells. We found that preferred orientations of clonally related cells are similar to each other, suggesting that cell lineage is involved in the development of response selectivity of neurons in the cortex. However, not all clonally related cells share response selectivity, suggesting that cell lineage is not the only determinant of response selectivity.
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UR - http://www.scopus.com/inward/citedby.url?scp=84863850989&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2012.05.023
DO - 10.1016/j.neuron.2012.05.023
M3 - Article
C2 - 22794261
AN - SCOPUS:84863850989
VL - 75
SP - 65
EP - 72
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 1
ER -