TY - JOUR
T1 - Simple and rapid analytical method for carbapenems using capillary zone electrophoresis
AU - Taniguchi, Shoko
AU - Hamase, Kenji
AU - Kinoshita, Akio
AU - Zaitsu, Kiyoshi
N1 - Funding Information:
We wish to thank Sankyo Co., Ltd., Takeda Chemical Industries, Ltd., Hoechst Marion Roussel Co., Ltd., Shionogi and Co., Ltd., Banyu Pharmaceutical Co., Ltd. and Sumitomo Pharmaceuticals Co., Ltd., for the generous gift of the drug substances of carbapenems and β-lactams. We also wish to thank Dr. S. Kanda, Dr. Y. Arakawa and Dr. K. Kimoto for the their kind advice on the prescription of carbapenems. This work was supported in part by a Grant-in-Aid from the Human Science Foundation.
PY - 1999/4/30
Y1 - 1999/4/30
N2 - A simple and rapid analytical method for carbapenems using high-performance capillary electrophoresis is described. All therapeutic carbapenem injections in Japan (imipenem, panipenem and meropenem) and four other β-lactams (piperacillin, cefotiam, cefotaxime, latamoxef) were separated and determined with good repeatability in about 10 min using simple free zone capillary electrophoresis. The electrophoresis buffer was 100 mM phosphate buffer of pH 8.0, and a fused-silica capillary of 25 μm I.D. and 47 cm length was adopted. The present method was successfully applied to monitor the degradation of carbapenems under various conditions (at various temperatures or in coexistence with other drugs prescribed in the case of methicillin-resistant Staphylococcus aureus). Copyright (C) 1999 Elsevier Science B.V.
AB - A simple and rapid analytical method for carbapenems using high-performance capillary electrophoresis is described. All therapeutic carbapenem injections in Japan (imipenem, panipenem and meropenem) and four other β-lactams (piperacillin, cefotiam, cefotaxime, latamoxef) were separated and determined with good repeatability in about 10 min using simple free zone capillary electrophoresis. The electrophoresis buffer was 100 mM phosphate buffer of pH 8.0, and a fused-silica capillary of 25 μm I.D. and 47 cm length was adopted. The present method was successfully applied to monitor the degradation of carbapenems under various conditions (at various temperatures or in coexistence with other drugs prescribed in the case of methicillin-resistant Staphylococcus aureus). Copyright (C) 1999 Elsevier Science B.V.
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U2 - 10.1016/S0378-4347(99)00005-5
DO - 10.1016/S0378-4347(99)00005-5
M3 - Article
C2 - 10360441
AN - SCOPUS:0032922497
SN - 0378-4347
VL - 727
SP - 219
EP - 225
JO - Journal of Chromatography B: Biomedical Sciences and Applications
JF - Journal of Chromatography B: Biomedical Sciences and Applications
IS - 1-2
ER -