Simple and rapid analytical method for carbapenems using capillary zone electrophoresis

Shoko Taniguchi, Kenji Hamase, Akio Kinoshita, Kiyoshi Zaitsu

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

A simple and rapid analytical method for carbapenems using high-performance capillary electrophoresis is described. All therapeutic carbapenem injections in Japan (imipenem, panipenem and meropenem) and four other β-lactams (piperacillin, cefotiam, cefotaxime, latamoxef) were separated and determined with good repeatability in about 10 min using simple free zone capillary electrophoresis. The electrophoresis buffer was 100 mM phosphate buffer of pH 8.0, and a fused-silica capillary of 25 μm I.D. and 47 cm length was adopted. The present method was successfully applied to monitor the degradation of carbapenems under various conditions (at various temperatures or in coexistence with other drugs prescribed in the case of methicillin-resistant Staphylococcus aureus). Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)219-225
Number of pages7
JournalJournal of Chromatography B: Biomedical Sciences and Applications
Volume727
Issue number1-2
DOIs
Publication statusPublished - Apr 30 1999

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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