Simulation system for multiscale biological function models that require complex calculation scheme

Akira Amano, Florencio Punzalan Rusty, Takao Shimayoshi, Yoshitoshi Kunieda

Research output: Contribution to journalArticlepeer-review

Abstract

Many biological findings are continuously reported in the life science area. Most of them are reports on the correlations between some proteins, or correlations between some proteins and macroscopic phenomena such as whole body hemodynamics. In order to understand the underlying mechanisms of the biological systems, simulation and analysis of multiscale biological function models are considered useful. Since the complex calculation schemes are necessary to calculate these models efficiently, it is useful to represent both the biological function models and the calculation schemes in descriptive languages which are readable by the computer programs. In this report, we introduce our simulation system which generates simulation programs from biological function models and calculation schemes both described by description languages. Using our system, we were able to generate simulation programs for a hemodynamic simulation model coupling a ventricular myocyte model and a whole body circulation model, a simulation model that evaluates the changes in action potential of a ventricular myocyte model after drug administration, and a program that calculates the changes in action potential of ventricular myocytes by changing specific parameters.

Original languageEnglish
Pages (from-to)115-122
Number of pages8
JournalTransactions of Japanese Society for Medical and Biological Engineering
Volume53
Issue number3
DOIs
Publication statusPublished - Oct 29 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

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