Simultaneous determination of triazolam and its metabolites in human blood and urine by GC/MS

K. Kudo, N. Ikeda, Y. Hino

Research output: Contribution to journalArticlepeer-review

Abstract

A sensitive and selective method has been developed for simultaneous determination of triazolam and its major metabolites, α-hydroxytriazolam and 4-hydroxytriazolam in human whole blood and urine. The drugs were effectively extracted using a 3-step solvent extraction procedure followed by tert-butyldimethylsilyl derivatization, and subjected to GC/MS in the negative ion chemical ionization mode.

Original languageEnglish
Pages (from-to)137-143
Number of pages7
JournalZ Zagadnien Nauk Sadowych
Volume43
Publication statusPublished - 2000

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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