Simultaneous determination of triazolam and its metabolites in human blood and urine by GC/MS

Keiko Kudo, Noriaki Ikeda, Y. Hino

Research output: Contribution to journalArticle

Abstract

A sensitive and selective method has been developed for simultaneous determination of triazolam and its major metabolites, α-hydroxytriazolam and 4-hydroxytriazolam in human whole blood and urine. The drugs were effectively extracted using a 3-step solvent extraction procedure followed by tert-butyldimethylsilyl derivatization, and subjected to GC/MS in the negative ion chemical ionization mode.

Original languageEnglish
Pages (from-to)137-143
Number of pages7
JournalZ Zagadnien Nauk Sadowych
Volume43
Publication statusPublished - Jan 1 2000

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Triazolam
Urine
Ions
Pharmaceutical Preparations
4-hydroxytriazolam

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Simultaneous determination of triazolam and its metabolites in human blood and urine by GC/MS. / Kudo, Keiko; Ikeda, Noriaki; Hino, Y.

In: Z Zagadnien Nauk Sadowych, Vol. 43, 01.01.2000, p. 137-143.

Research output: Contribution to journalArticle

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