A sensitive and selective method has been developed for simultaneous determination of triazolam and its major metabolites, α-hydroxytriazolam and 4-hydroxytriazolam in human whole blood and urine. The drugs were effectively extracted using a 3-step solvent extraction procedure followed by tert-butyldimethylsilyl derivatization, and subjected to GC/MS in the negative ion chemical ionization mode.
|Number of pages||7|
|Journal||Z Zagadnien Nauk Sadowych|
|Publication status||Published - 2000|
All Science Journal Classification (ASJC) codes
- Pathology and Forensic Medicine