Single-Cell Memory Regulates a Neural Circuit for Sensory Behavior

Kyogo Kobayashi, Shunji Nakano, Mutsuki Amano, Daisuke Tsuboi, Tomoki Nishioka, Shingo Ikeda, Genta Yokoyama, Kozo Kaibuchi, Ikue Mori

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Unveiling the molecular and cellular mechanisms underlying memory has been a challenge for the past few decades. Although synaptic plasticity is proven to be essential for memory formation, the significance of "single-cell memory" still remains elusive. Here, we exploited a primary culture system for the analysis of C. elegans neurons and show that a single thermosensory neuron has an ability to form, retain, and reset a temperature memory. Genetic and proteomic analyses found that the expression of the single-cell memory exhibits inter-individual variability, which is controlled by the evolutionarily conserved CaMKI/IV and Raf pathway. The variable responses of a sensory neuron influenced the neural activity of downstream interneurons, suggesting that modulation of the sensory neurons ultimately determines the behavioral output in C. elegans. Our results provide proof of single-cell memory and suggest that the individual differences in neural responses at the single-cell level can confer individuality. Kobayashi et al. show that a single sensory neuron can memorize information without any neural connections and suggest that single-cell memory can underlie differences between individual responses.

Original languageEnglish
Pages (from-to)11-21
Number of pages11
JournalCell Reports
Volume14
Issue number1
DOIs
Publication statusPublished - Jan 5 2016

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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    Kobayashi, K., Nakano, S., Amano, M., Tsuboi, D., Nishioka, T., Ikeda, S., Yokoyama, G., Kaibuchi, K., & Mori, I. (2016). Single-Cell Memory Regulates a Neural Circuit for Sensory Behavior. Cell Reports, 14(1), 11-21. https://doi.org/10.1016/j.celrep.2015.11.064