Single channel recordings of calcium currents in chick cochlear hair cells

T. Kimitsuki, T. Nakagawa, K. Hisashi, S. Komune, S. Komiyama

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Abstract

Single Ca2+ channel currents were recorded from chick cochlear hair cells by using cell-attached patches. The elementary current was about - 2 pA at 70 mV positive to the resting potential (R.P.+ 70 mV); the slope conductance over a 40 mV voltage range was 24 pS. The open time histogram was reasonably well expressed by a single exponential function, while the closed time histogram was expressed by a sum of two exponential functions. The Ca2+ channel was activated around R.P.+ 60 mV and the average ensemble current did not decay during 130 ms depolarization, suggesting that the Ca2+ channel in chick cochlear hair cells is the L-type. The Ca2+ channel has three modes of gating behavior, expressed as current records with brief openings (mode 1), no openings (mode 0), or long-lasting openings and very brief closings (mode 2).

Original languageEnglish
Pages (from-to)144-148
Number of pages5
JournalActa Oto-Laryngologica
Volume114
Issue number2
DOIs
Publication statusPublished - Jan 1 1994

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All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

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