Single CX3CL1-Ig DNA administration enhances T cell priming in vivo

Mutsunori Iga, Alexandre Boissonnas, Brice Mahé, Olivia Bonduelle, Christophe Combadière, Behazine Combadière

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Upon antigenic stimulation, establishment of adaptive immune responses that determines vaccine efficacy is dependent on efficient T cell priming. Here, single CX3CL1-Ig DNA administration, a unique ligand of CX3CR1, together with viral or tumor antigens induced a strong in vivo antigen-specific T cell proliferation and effector function that was enough efficient to protect against a tumor challenge. We also showed that early expression of CX3CL1-Ig and antigens in muscle and lymphoid organs induces an increased in vivo migration of myeloid CD14+CD11c+ DC but not lymphoid CD8α+CD11c+ DC at these sites. Thus, by effectively directing DC toward lymphoid organs to encounter T cells, CX3CL1-Ig become a new candidate that augments T cell priming and increases efficiency of vaccination.

Original languageEnglish
Pages (from-to)4554-4563
Number of pages10
JournalVaccine
Volume25
Issue number23
DOIs
Publication statusPublished - Jun 6 2007

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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    Iga, M., Boissonnas, A., Mahé, B., Bonduelle, O., Combadière, C., & Combadière, B. (2007). Single CX3CL1-Ig DNA administration enhances T cell priming in vivo. Vaccine, 25(23), 4554-4563. https://doi.org/10.1016/j.vaccine.2007.04.028