Single-molecule measurements with a single quantum dot

Noritada Kaji, Manabu Tokeshi, Yoshinobu Baba

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

Recent progress of quantum dot (QD) applications in single-molecule measurements are reviewed in this paper. Bright fluorescence and anti-photobleaching properties of QDs have explored the way to conduct long-time trajectory tracking of transmembrane proteins both in vitro and in vivo. Coupled with diversities of chemical and biochemical modifications of QD surfaces, their application fields are expanding to multidiscipline fields including imaging on the basis of a single molecule. Currently, molecular interactions and conformational changes on the QD surface can be detected at a single-molecule level. These expansions of application fields also involve toxicity problems in cells since most commercially available QDs consist of cadmium selenide or cadmium telluride, which are inherently toxic. For widespread applications of QDs including in vivo and therapeutic use in place of current organic fluorophore, cytotoxicity is discussed as well in this paper.

Original languageEnglish
Pages (from-to)295-304
Number of pages10
JournalChemical Record
Volume7
Issue number5
DOIs
Publication statusPublished - Nov 27 2007
Externally publishedYes

Fingerprint

Quantum Dots
Semiconductor quantum dots
Molecules
Photobleaching
Poisons
Therapeutic Uses
Cadmium telluride
Molecular interactions
Fluorophores
Cytotoxicity
Fluorescence
Cadmium
Toxicity
Trajectories
Proteins
Imaging techniques

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry
  • Chemical Engineering(all)
  • Materials Chemistry

Cite this

Single-molecule measurements with a single quantum dot. / Kaji, Noritada; Tokeshi, Manabu; Baba, Yoshinobu.

In: Chemical Record, Vol. 7, No. 5, 27.11.2007, p. 295-304.

Research output: Contribution to journalReview article

Kaji, Noritada ; Tokeshi, Manabu ; Baba, Yoshinobu. / Single-molecule measurements with a single quantum dot. In: Chemical Record. 2007 ; Vol. 7, No. 5. pp. 295-304.
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