Abstract
Single neuron activity in the lateral hypothalamic area (LHA) was recorded extracellularly in freely moving rats. Intra-third-cerebroventricular injection of 2-deoxy-d-glucose (2-DG) increased the activity in 38% of 69 neurons and decreased it in 19%. The remaining 43% of the neurons were not affected. Of the neurons excited, 50% showed definite inhibition of activity after long-lasting excitation. In 58% of the 69 neurons, the following changes in neuronal activity were observed during spontaneous feeding. Most of the tonic type neurons, which increased activity throughout the period of a meal, were excited by 2-DG, while the phasic type, which showed an abrupt increase in activity just before eating followed by a decrease, tended to be inhibited by 2-DG. Although injection of 2-DG induced feeding for a brief period in 61 cases (88%), the total food intake during 24 h was reduced significantly below normal. These findings indicate that 2-DG both excites and inhibits LHA neurons and induces facilitation followed by inhibition of feeding behavior.
| Original language | English |
|---|---|
| Pages (from-to) | 1-9 |
| Number of pages | 9 |
| Journal | Brain Research |
| Volume | 359 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - Dec 16 1985 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology
Cite this
Single neuron activity in the rat lateral hypothalamus during 2-deoxy-d-glucose induced and natural feeding behavior. / Katafuchi, Toshihiko; Oomura, Yutaka; Yoshimatsu, Hironobu.
In: Brain Research, Vol. 359, No. 1-2, 16.12.1985, p. 1-9.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Single neuron activity in the rat lateral hypothalamus during 2-deoxy-d-glucose induced and natural feeding behavior
AU - Katafuchi, Toshihiko
AU - Oomura, Yutaka
AU - Yoshimatsu, Hironobu
PY - 1985/12/16
Y1 - 1985/12/16
N2 - Single neuron activity in the lateral hypothalamic area (LHA) was recorded extracellularly in freely moving rats. Intra-third-cerebroventricular injection of 2-deoxy-d-glucose (2-DG) increased the activity in 38% of 69 neurons and decreased it in 19%. The remaining 43% of the neurons were not affected. Of the neurons excited, 50% showed definite inhibition of activity after long-lasting excitation. In 58% of the 69 neurons, the following changes in neuronal activity were observed during spontaneous feeding. Most of the tonic type neurons, which increased activity throughout the period of a meal, were excited by 2-DG, while the phasic type, which showed an abrupt increase in activity just before eating followed by a decrease, tended to be inhibited by 2-DG. Although injection of 2-DG induced feeding for a brief period in 61 cases (88%), the total food intake during 24 h was reduced significantly below normal. These findings indicate that 2-DG both excites and inhibits LHA neurons and induces facilitation followed by inhibition of feeding behavior.
AB - Single neuron activity in the lateral hypothalamic area (LHA) was recorded extracellularly in freely moving rats. Intra-third-cerebroventricular injection of 2-deoxy-d-glucose (2-DG) increased the activity in 38% of 69 neurons and decreased it in 19%. The remaining 43% of the neurons were not affected. Of the neurons excited, 50% showed definite inhibition of activity after long-lasting excitation. In 58% of the 69 neurons, the following changes in neuronal activity were observed during spontaneous feeding. Most of the tonic type neurons, which increased activity throughout the period of a meal, were excited by 2-DG, while the phasic type, which showed an abrupt increase in activity just before eating followed by a decrease, tended to be inhibited by 2-DG. Although injection of 2-DG induced feeding for a brief period in 61 cases (88%), the total food intake during 24 h was reduced significantly below normal. These findings indicate that 2-DG both excites and inhibits LHA neurons and induces facilitation followed by inhibition of feeding behavior.
UR - http://www.scopus.com/inward/record.url?scp=0022357002&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022357002&partnerID=8YFLogxK
U2 - 10.1016/0006-8993(85)91406-4
DO - 10.1016/0006-8993(85)91406-4
M3 - Article
VL - 359
SP - 1
EP - 9
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1-2
ER -