Single neuron activity in the rat lateral hypothalamus during 2-deoxy-d-glucose induced and natural feeding behavior

Toshihiko Katafuchi, Yutaka Oomura, Hironobu Yoshimatsu

Research output: Contribution to journalArticle

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Abstract

Single neuron activity in the lateral hypothalamic area (LHA) was recorded extracellularly in freely moving rats. Intra-third-cerebroventricular injection of 2-deoxy-d-glucose (2-DG) increased the activity in 38% of 69 neurons and decreased it in 19%. The remaining 43% of the neurons were not affected. Of the neurons excited, 50% showed definite inhibition of activity after long-lasting excitation. In 58% of the 69 neurons, the following changes in neuronal activity were observed during spontaneous feeding. Most of the tonic type neurons, which increased activity throughout the period of a meal, were excited by 2-DG, while the phasic type, which showed an abrupt increase in activity just before eating followed by a decrease, tended to be inhibited by 2-DG. Although injection of 2-DG induced feeding for a brief period in 61 cases (88%), the total food intake during 24 h was reduced significantly below normal. These findings indicate that 2-DG both excites and inhibits LHA neurons and induces facilitation followed by inhibition of feeding behavior.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalBrain Research
Volume359
Issue number1-2
DOIs
Publication statusPublished - Dec 16 1985

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Lateral Hypothalamic Area
Feeding Behavior
Neurons
Glucose
Eating
Injections
Meals

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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Single neuron activity in the rat lateral hypothalamus during 2-deoxy-d-glucose induced and natural feeding behavior. / Katafuchi, Toshihiko; Oomura, Yutaka; Yoshimatsu, Hironobu.

In: Brain Research, Vol. 359, No. 1-2, 16.12.1985, p. 1-9.

Research output: Contribution to journalArticle

Katafuchi, Toshihiko ; Oomura, Yutaka ; Yoshimatsu, Hironobu. / Single neuron activity in the rat lateral hypothalamus during 2-deoxy-d-glucose induced and natural feeding behavior. In: Brain Research. 1985 ; Vol. 359, No. 1-2. pp. 1-9.
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