Single T factors predict survival of patients with resected stage-IIB non-small-cell lung cancers

Makoto Suzuki, Shigetoshi Yoshida, Yasumitsu Moriya, Hidehisa Hoshino, Teruaki Mizobuchi, Tatsuro Okamoto, Ichiro Yoshino

Research output: Contribution to journalArticle

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Abstract

Objective: In the seventh edition of TNM Classification of Malignant Tumours (TNM) staging, the stage-IIB category for lung cancer is comprised of four factors: lymph-node metastasis, chest-wall invasion, large tumor size (>7. cm), and same-lobe nodules. Tumors are further classified into eight sub-categories based on each TN factor or factor combinations. This study evaluated the prognostic value of each TN factor or combinations for resected stage-IIB non-small-cell lung cancer (NSCLC). Methods: We retrospectively studied 186 consecutive patients who had resections for NSCLC at Chiba University Hospital and were diagnosed as stage IIB according to the seventh edition of TNM staging. Results: Five-year survivals for each stage IIB were: T2bN1M0 = 47 ± 12% (± standard error); T3 (chest-wall invasion; N0M0) = 59 ± 7%; T3 (large tumor > 7 cm) = 72 ± 11%; T3 (same-lobe nodules) = 78 ± 5%; T3 (invasion + >7 cm) = 44 ± 16%; T3 (invasion + same-lobe nodules) = 25 ± 22%; T3 (>7 cm + same-lobe nodules) = 0%; and T3 (invasion + >7 cm + same-lobe nodules) = 0%. Among the four single factors, same-lobe nodules had the best prognoses, whereas T2bN1M0 had the worst prognoses. Comparing cases with single factors and multiple factors that decided stage IIB, cases with multiple factors had poorer prognoses (P = 0.02). Conclusion: The stage-IIB category is comprised of eight sub-categories, with either single factors or factor combinations; these sub-categories have different prognoses. The worst survivals were for cases with T2bN1M0 as a single factor or for cases with multiple factors, although these represented a small proportion of resected stage-IIB NSCLC cases.

Original languageEnglish
Pages (from-to)745-748
Number of pages4
JournalEuropean Journal of Cardio-thoracic Surgery
Volume39
Issue number5
DOIs
Publication statusPublished - May 1 2011

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Neoplasm Staging
Non-Small Cell Lung Carcinoma
Survival
Thoracic Wall
Neoplasms
Lung Neoplasms
Lymph Nodes
Neoplasm Metastasis

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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Single T factors predict survival of patients with resected stage-IIB non-small-cell lung cancers. / Suzuki, Makoto; Yoshida, Shigetoshi; Moriya, Yasumitsu; Hoshino, Hidehisa; Mizobuchi, Teruaki; Okamoto, Tatsuro; Yoshino, Ichiro.

In: European Journal of Cardio-thoracic Surgery, Vol. 39, No. 5, 01.05.2011, p. 745-748.

Research output: Contribution to journalArticle

Suzuki, M, Yoshida, S, Moriya, Y, Hoshino, H, Mizobuchi, T, Okamoto, T & Yoshino, I 2011, 'Single T factors predict survival of patients with resected stage-IIB non-small-cell lung cancers', European Journal of Cardio-thoracic Surgery, vol. 39, no. 5, pp. 745-748. https://doi.org/10.1016/j.ejcts.2010.08.014
Suzuki, Makoto ; Yoshida, Shigetoshi ; Moriya, Yasumitsu ; Hoshino, Hidehisa ; Mizobuchi, Teruaki ; Okamoto, Tatsuro ; Yoshino, Ichiro. / Single T factors predict survival of patients with resected stage-IIB non-small-cell lung cancers. In: European Journal of Cardio-thoracic Surgery. 2011 ; Vol. 39, No. 5. pp. 745-748.
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abstract = "Objective: In the seventh edition of TNM Classification of Malignant Tumours (TNM) staging, the stage-IIB category for lung cancer is comprised of four factors: lymph-node metastasis, chest-wall invasion, large tumor size (>7. cm), and same-lobe nodules. Tumors are further classified into eight sub-categories based on each TN factor or factor combinations. This study evaluated the prognostic value of each TN factor or combinations for resected stage-IIB non-small-cell lung cancer (NSCLC). Methods: We retrospectively studied 186 consecutive patients who had resections for NSCLC at Chiba University Hospital and were diagnosed as stage IIB according to the seventh edition of TNM staging. Results: Five-year survivals for each stage IIB were: T2bN1M0 = 47 ± 12{\%} (± standard error); T3 (chest-wall invasion; N0M0) = 59 ± 7{\%}; T3 (large tumor > 7 cm) = 72 ± 11{\%}; T3 (same-lobe nodules) = 78 ± 5{\%}; T3 (invasion + >7 cm) = 44 ± 16{\%}; T3 (invasion + same-lobe nodules) = 25 ± 22{\%}; T3 (>7 cm + same-lobe nodules) = 0{\%}; and T3 (invasion + >7 cm + same-lobe nodules) = 0{\%}. Among the four single factors, same-lobe nodules had the best prognoses, whereas T2bN1M0 had the worst prognoses. Comparing cases with single factors and multiple factors that decided stage IIB, cases with multiple factors had poorer prognoses (P = 0.02). Conclusion: The stage-IIB category is comprised of eight sub-categories, with either single factors or factor combinations; these sub-categories have different prognoses. The worst survivals were for cases with T2bN1M0 as a single factor or for cases with multiple factors, although these represented a small proportion of resected stage-IIB NSCLC cases.",
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T1 - Single T factors predict survival of patients with resected stage-IIB non-small-cell lung cancers

AU - Suzuki, Makoto

AU - Yoshida, Shigetoshi

AU - Moriya, Yasumitsu

AU - Hoshino, Hidehisa

AU - Mizobuchi, Teruaki

AU - Okamoto, Tatsuro

AU - Yoshino, Ichiro

PY - 2011/5/1

Y1 - 2011/5/1

N2 - Objective: In the seventh edition of TNM Classification of Malignant Tumours (TNM) staging, the stage-IIB category for lung cancer is comprised of four factors: lymph-node metastasis, chest-wall invasion, large tumor size (>7. cm), and same-lobe nodules. Tumors are further classified into eight sub-categories based on each TN factor or factor combinations. This study evaluated the prognostic value of each TN factor or combinations for resected stage-IIB non-small-cell lung cancer (NSCLC). Methods: We retrospectively studied 186 consecutive patients who had resections for NSCLC at Chiba University Hospital and were diagnosed as stage IIB according to the seventh edition of TNM staging. Results: Five-year survivals for each stage IIB were: T2bN1M0 = 47 ± 12% (± standard error); T3 (chest-wall invasion; N0M0) = 59 ± 7%; T3 (large tumor > 7 cm) = 72 ± 11%; T3 (same-lobe nodules) = 78 ± 5%; T3 (invasion + >7 cm) = 44 ± 16%; T3 (invasion + same-lobe nodules) = 25 ± 22%; T3 (>7 cm + same-lobe nodules) = 0%; and T3 (invasion + >7 cm + same-lobe nodules) = 0%. Among the four single factors, same-lobe nodules had the best prognoses, whereas T2bN1M0 had the worst prognoses. Comparing cases with single factors and multiple factors that decided stage IIB, cases with multiple factors had poorer prognoses (P = 0.02). Conclusion: The stage-IIB category is comprised of eight sub-categories, with either single factors or factor combinations; these sub-categories have different prognoses. The worst survivals were for cases with T2bN1M0 as a single factor or for cases with multiple factors, although these represented a small proportion of resected stage-IIB NSCLC cases.

AB - Objective: In the seventh edition of TNM Classification of Malignant Tumours (TNM) staging, the stage-IIB category for lung cancer is comprised of four factors: lymph-node metastasis, chest-wall invasion, large tumor size (>7. cm), and same-lobe nodules. Tumors are further classified into eight sub-categories based on each TN factor or factor combinations. This study evaluated the prognostic value of each TN factor or combinations for resected stage-IIB non-small-cell lung cancer (NSCLC). Methods: We retrospectively studied 186 consecutive patients who had resections for NSCLC at Chiba University Hospital and were diagnosed as stage IIB according to the seventh edition of TNM staging. Results: Five-year survivals for each stage IIB were: T2bN1M0 = 47 ± 12% (± standard error); T3 (chest-wall invasion; N0M0) = 59 ± 7%; T3 (large tumor > 7 cm) = 72 ± 11%; T3 (same-lobe nodules) = 78 ± 5%; T3 (invasion + >7 cm) = 44 ± 16%; T3 (invasion + same-lobe nodules) = 25 ± 22%; T3 (>7 cm + same-lobe nodules) = 0%; and T3 (invasion + >7 cm + same-lobe nodules) = 0%. Among the four single factors, same-lobe nodules had the best prognoses, whereas T2bN1M0 had the worst prognoses. Comparing cases with single factors and multiple factors that decided stage IIB, cases with multiple factors had poorer prognoses (P = 0.02). Conclusion: The stage-IIB category is comprised of eight sub-categories, with either single factors or factor combinations; these sub-categories have different prognoses. The worst survivals were for cases with T2bN1M0 as a single factor or for cases with multiple factors, although these represented a small proportion of resected stage-IIB NSCLC cases.

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