Sinulobatins A ~ D, new amphilectane-type diterpenoids from the Japanese soft coral Sinularia nanolobata

Koji Yamada, Tami Ujiie, Katsumi Yoshida, Tomofumi Miyamoto, Ryuichi Higuchi

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Four new amphilectane-type diterpenoids, sinulobatins A (1), B (2), C (3) and D (4) were isolated from the Japanese soft coral Sinularia nanolobata. Their structures were determined based on spectroscopic evidence and single crystal X-ray analysis. The absolute stereochemistry of 1 was elucidated on the basis of its CD spectrum. These compounds exhibited cytotoxicity against L1210 cells and KB cells in vitro with IC50 values of 3.0-7.7 μg/mL.

Original languageEnglish
Pages (from-to)4569-4578
Number of pages10
JournalTetrahedron
Volume53
Issue number13
DOIs
Publication statusPublished - Mar 31 1997

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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