Four new amphilectane-type diterpenoids, sinulobatins A (1), B (2), C (3) and D (4) were isolated from the Japanese soft coral Sinularia nanolobata. Their structures were determined based on spectroscopic evidence and single crystal X-ray analysis. The absolute stereochemistry of 1 was elucidated on the basis of its CD spectrum. These compounds exhibited cytotoxicity against L1210 cells and KB cells in vitro with IC50 values of 3.0-7.7 μg/mL.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry