Sinulobatins A ~ D, new amphilectane-type diterpenoids from the Japanese soft coral Sinularia nanolobata

Koji Yamada, Tami Ujiie, Katsumi Yoshida, Tomofumi Miyamoto, Ryuichi Higuchi

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Four new amphilectane-type diterpenoids, sinulobatins A (1), B (2), C (3) and D (4) were isolated from the Japanese soft coral Sinularia nanolobata. Their structures were determined based on spectroscopic evidence and single crystal X-ray analysis. The absolute stereochemistry of 1 was elucidated on the basis of its CD spectrum. These compounds exhibited cytotoxicity against L1210 cells and KB cells in vitro with IC50 values of 3.0-7.7 μg/mL.

Original languageEnglish
Pages (from-to)4569-4578
Number of pages10
JournalTetrahedron
Volume53
Issue number13
DOIs
Publication statusPublished - Mar 31 1997

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KB Cells
Anthozoa
Stereochemistry
Diterpenes
X ray analysis
Cytotoxicity
Inhibitory Concentration 50
X-Rays
Single crystals
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Sinulobatins A ~ D, new amphilectane-type diterpenoids from the Japanese soft coral Sinularia nanolobata. / Yamada, Koji; Ujiie, Tami; Yoshida, Katsumi; Miyamoto, Tomofumi; Higuchi, Ryuichi.

In: Tetrahedron, Vol. 53, No. 13, 31.03.1997, p. 4569-4578.

Research output: Contribution to journalArticle

Yamada, Koji ; Ujiie, Tami ; Yoshida, Katsumi ; Miyamoto, Tomofumi ; Higuchi, Ryuichi. / Sinulobatins A ~ D, new amphilectane-type diterpenoids from the Japanese soft coral Sinularia nanolobata. In: Tetrahedron. 1997 ; Vol. 53, No. 13. pp. 4569-4578.
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