Abstract
The ring-shaped cohesin complex links sister chromatids and plays crucial roles in homologous recombination and mitotic chromosome segregation. In cycling cells, cohesin's ability to generate cohesive linkages is restricted to S phase and depends on loading and establishment factors that are intimately connected to DNA replication. Here we review how cohesin is regulated by the replication machinery, as well as recent evidence that cohesin itself influences how chromosomes are replicated.
Original language | English |
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Pages (from-to) | 2723-2731 |
Number of pages | 9 |
Journal | Genes and Development |
Volume | 24 |
Issue number | 24 |
DOIs | |
Publication status | Published - Dec 15 2010 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Genetics
- Developmental Biology