Sister acts: Coordinating DNA replication and cohesion establishment

Rebecca Sherwood; Tatsuro S. Takahashi; Prasad V. Jallepalli

doi:10.1101/gad.1976710

Sister acts: Coordinating DNA replication and cohesion establishment

Rebecca Sherwood, Tatsuro S. Takahashi, Prasad V. Jallepalli

Research output: Contribution to journal › Review article › peer-review

57 Citations (Scopus)

Abstract

The ring-shaped cohesin complex links sister chromatids and plays crucial roles in homologous recombination and mitotic chromosome segregation. In cycling cells, cohesin's ability to generate cohesive linkages is restricted to S phase and depends on loading and establishment factors that are intimately connected to DNA replication. Here we review how cohesin is regulated by the replication machinery, as well as recent evidence that cohesin itself influences how chromosomes are replicated.

Original language	English
Pages (from-to)	2723-2731
Number of pages	9
Journal	Genes and Development
Volume	24
Issue number	24
DOIs	https://doi.org/10.1101/gad.1976710
Publication status	Published - Dec 15 2010
Externally published	Yes

All Science Journal Classification (ASJC) codes

Genetics
Developmental Biology

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10.1101/gad.1976710

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abstract = "The ring-shaped cohesin complex links sister chromatids and plays crucial roles in homologous recombination and mitotic chromosome segregation. In cycling cells, cohesin's ability to generate cohesive linkages is restricted to S phase and depends on loading and establishment factors that are intimately connected to DNA replication. Here we review how cohesin is regulated by the replication machinery, as well as recent evidence that cohesin itself influences how chromosomes are replicated.",

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AB - The ring-shaped cohesin complex links sister chromatids and plays crucial roles in homologous recombination and mitotic chromosome segregation. In cycling cells, cohesin's ability to generate cohesive linkages is restricted to S phase and depends on loading and establishment factors that are intimately connected to DNA replication. Here we review how cohesin is regulated by the replication machinery, as well as recent evidence that cohesin itself influences how chromosomes are replicated.

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Sister acts: Coordinating DNA replication and cohesion establishment

Abstract

All Science Journal Classification (ASJC) codes

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