Sister acts: Coordinating DNA replication and cohesion establishment

Rebecca Sherwood, Tatsuro S. Takahashi, Prasad V. Jallepalli

Research output: Contribution to journalReview article

51 Citations (Scopus)

Abstract

The ring-shaped cohesin complex links sister chromatids and plays crucial roles in homologous recombination and mitotic chromosome segregation. In cycling cells, cohesin's ability to generate cohesive linkages is restricted to S phase and depends on loading and establishment factors that are intimately connected to DNA replication. Here we review how cohesin is regulated by the replication machinery, as well as recent evidence that cohesin itself influences how chromosomes are replicated.

Original languageEnglish
Pages (from-to)2723-2731
Number of pages9
JournalGenes and Development
Volume24
Issue number24
DOIs
Publication statusPublished - Dec 15 2010

All Science Journal Classification (ASJC) codes

  • Genetics
  • Developmental Biology

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