Abstract
The ring-shaped cohesin complex links sister chromatids and plays crucial roles in homologous recombination and mitotic chromosome segregation. In cycling cells, cohesin's ability to generate cohesive linkages is restricted to S phase and depends on loading and establishment factors that are intimately connected to DNA replication. Here we review how cohesin is regulated by the replication machinery, as well as recent evidence that cohesin itself influences how chromosomes are replicated.
| Original language | English |
|---|---|
| Pages (from-to) | 2723-2731 |
| Number of pages | 9 |
| Journal | Genes and Development |
| Volume | 24 |
| Issue number | 24 |
| DOIs | |
| Publication status | Published - Dec 15 2010 |
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All Science Journal Classification (ASJC) codes
- Genetics
- Developmental Biology
Cite this
Sister acts : Coordinating DNA replication and cohesion establishment. / Sherwood, Rebecca; Takahashi, Tatsuro S.; Jallepalli, Prasad V.
In: Genes and Development, Vol. 24, No. 24, 15.12.2010, p. 2723-2731.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Sister acts
T2 - Coordinating DNA replication and cohesion establishment
AU - Sherwood, Rebecca
AU - Takahashi, Tatsuro S.
AU - Jallepalli, Prasad V.
PY - 2010/12/15
Y1 - 2010/12/15
N2 - The ring-shaped cohesin complex links sister chromatids and plays crucial roles in homologous recombination and mitotic chromosome segregation. In cycling cells, cohesin's ability to generate cohesive linkages is restricted to S phase and depends on loading and establishment factors that are intimately connected to DNA replication. Here we review how cohesin is regulated by the replication machinery, as well as recent evidence that cohesin itself influences how chromosomes are replicated.
AB - The ring-shaped cohesin complex links sister chromatids and plays crucial roles in homologous recombination and mitotic chromosome segregation. In cycling cells, cohesin's ability to generate cohesive linkages is restricted to S phase and depends on loading and establishment factors that are intimately connected to DNA replication. Here we review how cohesin is regulated by the replication machinery, as well as recent evidence that cohesin itself influences how chromosomes are replicated.
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UR - http://www.scopus.com/inward/citedby.url?scp=78650226331&partnerID=8YFLogxK
U2 - 10.1101/gad.1976710
DO - 10.1101/gad.1976710
M3 - Review article
C2 - 21159813
AN - SCOPUS:78650226331
VL - 24
SP - 2723
EP - 2731
JO - Genes and Development
JF - Genes and Development
SN - 0890-9369
IS - 24
ER -