Site-directed alkylation to cytidine within duplex by the oligonucleotides containing functional nucleobases

F. Nagatsugi, T. Kawasaki, N. Tokuda, M. Maeda, Shigeki Sasaki

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

We have previously described that oligonucleotides (ODN) containing phenylsulfoxide derivative of 2-amino-6-vinylpurine nucleoside analog (1) are activated within duplex to form cross-link toward cytidine selectively at the target site. In this paper, we wish to report the search for more stable precursor susceptible for activation within duplex.

Original languageEnglish
Pages (from-to)915-919
Number of pages5
JournalNucleosides, Nucleotides and Nucleic Acids
Volume20
Issue number4-7
DOIs
Publication statusPublished - 2001

All Science Journal Classification (ASJC) codes

  • Genetics
  • Biochemistry

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